TY - JOUR
T1 - Involvement of Annexins I an II in human liver cirrhosis and hepatocellular carcinoma
AU - Masaki, Tsutomu
AU - Tokuda, Masaaki
AU - Ohnishi, Makoto
AU - Tai, Yuji
AU - Itano, Toshifumi
AU - Matsui, Hideki
AU - Watanabe, Seishiro
AU - Arima, Keiji
AU - Kohno, Kazumi
AU - Maeba, Takashi
AU - Ikeda, Yosikazu
AU - Hatase, Osamu
AU - Nishioka, Mikio
N1 - Funding Information:
We thank the staff of the Common Equipment Research Center of the Kagawa Medical School for their technical assistance. This work was supported by a Grant-in-Aid for Scientific Research from the Ministry of Education, Science and Culture of Japan.
PY - 1995/8
Y1 - 1995/8
N2 - Annexin (AX) is the name of a new family of Ca2+-dependent membrane binding proteins of which 13 members have been reported to date. Among these, AXI and AXII have been reported to possess many biological functions in vitro. Their actual roles in vivo, however, are as yet unknown. There have been no reports previously demonstrating the direct involvement of AXI and AXII in chronic hepatitis (CH), liver cirrhosis (LC) or hepatocellular carcinoma (HCC). The involvement of AXI and AXII in the etiological processes of CH, LC and HCC was investigated by Western blot and/or immunohistochemistry using anti-AXI and AXII antibodies. AXI and AXII were rarely detected in CH liver tissues, while they were found to be expressed at high levels in LC and HCC. AXI and AXII were present in the hepatocytes of LC and HCC and their subcellular localization was mainly cytoplasmic. These results indicate that AXI and AXII may act together in the occurrence and development of LC and HCC.
AB - Annexin (AX) is the name of a new family of Ca2+-dependent membrane binding proteins of which 13 members have been reported to date. Among these, AXI and AXII have been reported to possess many biological functions in vitro. Their actual roles in vivo, however, are as yet unknown. There have been no reports previously demonstrating the direct involvement of AXI and AXII in chronic hepatitis (CH), liver cirrhosis (LC) or hepatocellular carcinoma (HCC). The involvement of AXI and AXII in the etiological processes of CH, LC and HCC was investigated by Western blot and/or immunohistochemistry using anti-AXI and AXII antibodies. AXI and AXII were rarely detected in CH liver tissues, while they were found to be expressed at high levels in LC and HCC. AXI and AXII were present in the hepatocytes of LC and HCC and their subcellular localization was mainly cytoplasmic. These results indicate that AXI and AXII may act together in the occurrence and development of LC and HCC.
KW - Annexin
KW - Hepatocellular carcinoma
KW - Liver cirrhosis
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U2 - 10.1016/0928-4346(95)00213-3
DO - 10.1016/0928-4346(95)00213-3
M3 - Article
AN - SCOPUS:0029111480
SN - 0928-4346
VL - 4
SP - 113
EP - 119
JO - International Hepatology Communications
JF - International Hepatology Communications
IS - 2
ER -
