Involvement of Ca2+-calmodulin-dependent protein kinase II in the intestinal secretory action of Escherichia coli heat-stable enterotoxin II

Yoshio Fujii; Tomohiko Nomura; Hiroyasu Yamanaka; Keinosuke Okamoto

doi:10.1111/j.1348-0421.1997.tb01904.x

Involvement of Ca²⁺-calmodulin-dependent protein kinase II in the intestinal secretory action of Escherichia coli heat-stable enterotoxin II

Yoshio Fujii, Tomohiko Nomura, Hiroyasu Yamanaka, Keinosuke Okamoto

Research output: Contribution to journal › Article › peer-review

26 Citations (Scopus)

Abstract

Treating the mouse intestine with the calmodulin antagonist W-7 and KN- 93, an inhibitor of Ca²⁺-calmodulin-dependent protein kinase II (CaMK II), reduced the sensitivity of the host to the action of Escherichia coli heat- stable enterotoxin II (STII). CaMK II activity in mouse intestinal cells increased after exposure to STII. These results indicate that CaMK II is involved in the mechanism of action of STII.

Original language	English
Pages (from-to)	633-636
Number of pages	4
Journal	MICROBIOLOGY and IMMUNOLOGY
Volume	41
Issue number	8
DOIs	https://doi.org/10.1111/j.1348-0421.1997.tb01904.x
Publication status	Published - 1997
Externally published	Yes

Keywords

Calmodulin
Enterotoxin
Escherichia coli

ASJC Scopus subject areas

Microbiology
Immunology
Virology

Access to Document

10.1111/j.1348-0421.1997.tb01904.x

Cite this

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abstract = "Treating the mouse intestine with the calmodulin antagonist W-7 and KN- 93, an inhibitor of Ca2+-calmodulin-dependent protein kinase II (CaMK II), reduced the sensitivity of the host to the action of Escherichia coli heat- stable enterotoxin II (STII). CaMK II activity in mouse intestinal cells increased after exposure to STII. These results indicate that CaMK II is involved in the mechanism of action of STII.",

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AU - Fujii, Yoshio

AU - Nomura, Tomohiko

AU - Yamanaka, Hiroyasu

AU - Okamoto, Keinosuke

PY - 1997

Y1 - 1997

N2 - Treating the mouse intestine with the calmodulin antagonist W-7 and KN- 93, an inhibitor of Ca2+-calmodulin-dependent protein kinase II (CaMK II), reduced the sensitivity of the host to the action of Escherichia coli heat- stable enterotoxin II (STII). CaMK II activity in mouse intestinal cells increased after exposure to STII. These results indicate that CaMK II is involved in the mechanism of action of STII.

AB - Treating the mouse intestine with the calmodulin antagonist W-7 and KN- 93, an inhibitor of Ca2+-calmodulin-dependent protein kinase II (CaMK II), reduced the sensitivity of the host to the action of Escherichia coli heat- stable enterotoxin II (STII). CaMK II activity in mouse intestinal cells increased after exposure to STII. These results indicate that CaMK II is involved in the mechanism of action of STII.

KW - Calmodulin

KW - Enterotoxin

KW - Escherichia coli

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