TY - JOUR
T1 - Involvement of the mechanoreceptors in the sensory mechanisms of manual and electrical acupuncture
AU - Yamamoto, Hiromi
AU - Kawada, Toru
AU - Kamiya, Atsunori
AU - Miyazaki, Shunichi
AU - Sugimachi, Masaru
N1 - Funding Information:
This study was supported by Health and Labour Sciences Research Grants ( H19-nano-Ippan-009, H20-katsudo-Shitei-007, and H21-nano-Ippan-005 ) from the Ministry of Health, Labour and Welfare of Japan ; by a Grant-in-Aid for Scientific Research (No. 20390462 ) from the Ministry of Education, Culture, Sports, Science and Technology of Japan ; and by the Industrial Technology Research Grant Program from the New Energy and Industrial Technology Development Organization (NEDO) of Japan .
PY - 2011/2/24
Y1 - 2011/2/24
N2 - The modalities of acupuncture can be broadly classified into manual acupuncture (MA) and electroacupuncture (EA). Although MA has been reported to cause winding of tissue around the needle and subsequent activation of the sensory mechanoreceptors and nociceptors, the sensory mechanisms of acupuncture stimulation are not fully understood. To test the hypothesis that the involvement of the mechanoreceptors in the sensory mechanism is different in MA and EA, we examined the effects of a stretch-activated channel blocker gadolinium on the hemodynamic responses to hind limb MA and EA in anesthetized rats (n. =9). Gadolinium significantly attenuated the MA-induced bradycardic response (-22 ± 5 vs. -10 ± 3 bpm, P < 0.05) and tended to attenuate the MA-induced depressor response (-30 ±5 vs. -18 ±4 mm Hg, P=0.06). On the other hand, gadolinium significantly attenuated both the EA-induced bradycardic (-22 ±5 vs. -9 ±4. bpm, P < 0.01) and depressor responses (-32 ±6 vs. -15 ±5. mm. Hg, P < 0.01). These results indicate that the mechanoreceptors are involved in the sensory mechanisms for both MA and EA.
AB - The modalities of acupuncture can be broadly classified into manual acupuncture (MA) and electroacupuncture (EA). Although MA has been reported to cause winding of tissue around the needle and subsequent activation of the sensory mechanoreceptors and nociceptors, the sensory mechanisms of acupuncture stimulation are not fully understood. To test the hypothesis that the involvement of the mechanoreceptors in the sensory mechanism is different in MA and EA, we examined the effects of a stretch-activated channel blocker gadolinium on the hemodynamic responses to hind limb MA and EA in anesthetized rats (n. =9). Gadolinium significantly attenuated the MA-induced bradycardic response (-22 ± 5 vs. -10 ± 3 bpm, P < 0.05) and tended to attenuate the MA-induced depressor response (-30 ±5 vs. -18 ±4 mm Hg, P=0.06). On the other hand, gadolinium significantly attenuated both the EA-induced bradycardic (-22 ±5 vs. -9 ±4. bpm, P < 0.01) and depressor responses (-32 ±6 vs. -15 ±5. mm. Hg, P < 0.01). These results indicate that the mechanoreceptors are involved in the sensory mechanisms for both MA and EA.
KW - Acupuncture
KW - Aortic depressor nerve
KW - Arterial blood pressure
KW - Gadolinium
KW - Heart rate
KW - Mechanoreceptor
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U2 - 10.1016/j.autneu.2010.11.004
DO - 10.1016/j.autneu.2010.11.004
M3 - Article
C2 - 21167796
AN - SCOPUS:79551539842
SN - 1566-0702
VL - 160
SP - 27
EP - 31
JO - Journal of the Autonomic Nervous System
JF - Journal of the Autonomic Nervous System
IS - 1-2
ER -