Ion-exchange resins modified with metal-porphyrin as a catalysis for oxidation of epinephrine (adrenaline)

Youji Kitamura; Masaki Mifune; Tsutomu Takatsuki; Toshinobu Iwasaki; Mayu Kawamoto; Akimasa Iwado; Masahiko Chikuma; Yutaka Saito

doi:10.1016/j.catcom.2007.06.005

Ion-exchange resins modified with metal-porphyrin as a catalysis for oxidation of epinephrine (adrenaline)

Youji Kitamura, Masaki Mifune, Tsutomu Takatsuki, Toshinobu Iwasaki, Mayu Kawamoto, Akimasa Iwado, Masahiko Chikuma, Yutaka Saito

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

To develop a solid catalyst which can be a model of catechol oxidase and/or catecholamine monoamine oxidase, the ion-exchange resins modified with metal-tetrakis(4-sulfophenyl)porphine (M-TSPP wherein M is Mn³⁺, Co³⁺, Fe³⁺ or Cu²⁺) were examined for a catalytic activity in the oxidative reaction of epinephrine (adrenaline, Ad). Among M-TSPP-modified resins (M-TSPP_rs), Mn-TSPP_r exhibited the strongest catalytic activity in the oxidation of Ad with O₂ in the air to adrenochrome and adrenolutin. Mn-TSPP had little catalytic activity in an aqueous solution of Ad. The optimum conditions for the oxidation reaction catalyzed by Mn-TSPP_r were determined. Oxidation of catecholamines and related compounds thereof were conducted under the optimum conditions thus determined, which revealed that Mn-TSPP_r only catalyzes oxidation of catecholamines.

Original language	English
Pages (from-to)	224-228
Number of pages	5
Journal	Catalysis Communications
Volume	9
Issue number	2
DOIs	https://doi.org/10.1016/j.catcom.2007.06.005
Publication status	Published - Feb 2008

Keywords

Catalysis
Catecholamine
Epinephrine
Immobilization
Metal-porphyrin
Mimetic
Oxidation

ASJC Scopus subject areas

Catalysis
Chemistry(all)
Process Chemistry and Technology

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10.1016/j.catcom.2007.06.005

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title = "Ion-exchange resins modified with metal-porphyrin as a catalysis for oxidation of epinephrine (adrenaline)",

abstract = "To develop a solid catalyst which can be a model of catechol oxidase and/or catecholamine monoamine oxidase, the ion-exchange resins modified with metal-tetrakis(4-sulfophenyl)porphine (M-TSPP wherein M is Mn3+, Co3+, Fe3+ or Cu2+) were examined for a catalytic activity in the oxidative reaction of epinephrine (adrenaline, Ad). Among M-TSPP-modified resins (M-TSPPrs), Mn-TSPPr exhibited the strongest catalytic activity in the oxidation of Ad with O2 in the air to adrenochrome and adrenolutin. Mn-TSPP had little catalytic activity in an aqueous solution of Ad. The optimum conditions for the oxidation reaction catalyzed by Mn-TSPPr were determined. Oxidation of catecholamines and related compounds thereof were conducted under the optimum conditions thus determined, which revealed that Mn-TSPPr only catalyzes oxidation of catecholamines.",

keywords = "Catalysis, Catecholamine, Epinephrine, Immobilization, Metal-porphyrin, Mimetic, Oxidation",

author = "Youji Kitamura and Masaki Mifune and Tsutomu Takatsuki and Toshinobu Iwasaki and Mayu Kawamoto and Akimasa Iwado and Masahiko Chikuma and Yutaka Saito",

year = "2008",

month = feb,

doi = "10.1016/j.catcom.2007.06.005",

language = "English",

volume = "9",

pages = "224--228",

journal = "Catalysis Communications",

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T1 - Ion-exchange resins modified with metal-porphyrin as a catalysis for oxidation of epinephrine (adrenaline)

AU - Kitamura, Youji

AU - Mifune, Masaki

AU - Takatsuki, Tsutomu

AU - Iwasaki, Toshinobu

AU - Kawamoto, Mayu

AU - Iwado, Akimasa

AU - Chikuma, Masahiko

AU - Saito, Yutaka

PY - 2008/2

Y1 - 2008/2

N2 - To develop a solid catalyst which can be a model of catechol oxidase and/or catecholamine monoamine oxidase, the ion-exchange resins modified with metal-tetrakis(4-sulfophenyl)porphine (M-TSPP wherein M is Mn3+, Co3+, Fe3+ or Cu2+) were examined for a catalytic activity in the oxidative reaction of epinephrine (adrenaline, Ad). Among M-TSPP-modified resins (M-TSPPrs), Mn-TSPPr exhibited the strongest catalytic activity in the oxidation of Ad with O2 in the air to adrenochrome and adrenolutin. Mn-TSPP had little catalytic activity in an aqueous solution of Ad. The optimum conditions for the oxidation reaction catalyzed by Mn-TSPPr were determined. Oxidation of catecholamines and related compounds thereof were conducted under the optimum conditions thus determined, which revealed that Mn-TSPPr only catalyzes oxidation of catecholamines.

AB - To develop a solid catalyst which can be a model of catechol oxidase and/or catecholamine monoamine oxidase, the ion-exchange resins modified with metal-tetrakis(4-sulfophenyl)porphine (M-TSPP wherein M is Mn3+, Co3+, Fe3+ or Cu2+) were examined for a catalytic activity in the oxidative reaction of epinephrine (adrenaline, Ad). Among M-TSPP-modified resins (M-TSPPrs), Mn-TSPPr exhibited the strongest catalytic activity in the oxidation of Ad with O2 in the air to adrenochrome and adrenolutin. Mn-TSPP had little catalytic activity in an aqueous solution of Ad. The optimum conditions for the oxidation reaction catalyzed by Mn-TSPPr were determined. Oxidation of catecholamines and related compounds thereof were conducted under the optimum conditions thus determined, which revealed that Mn-TSPPr only catalyzes oxidation of catecholamines.

KW - Catalysis

KW - Catecholamine

KW - Epinephrine

KW - Immobilization

KW - Metal-porphyrin

KW - Mimetic

KW - Oxidation

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U2 - 10.1016/j.catcom.2007.06.005

DO - 10.1016/j.catcom.2007.06.005

M3 - Article

AN - SCOPUS:36348954872

SN - 1566-7367

VL - 9

SP - 224

EP - 228

JO - Catalysis Communications

JF - Catalysis Communications

IS - 2

ER -

Ion-exchange resins modified with metal-porphyrin as a catalysis for oxidation of epinephrine (adrenaline)

Abstract

Keywords

ASJC Scopus subject areas

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