iPS cells and iN cells

Toru Yamashita, Koji Abe

Research output: Chapter in Book/Report/Conference proceedingChapter


The discovery of iPS indicated that overexpression of master transcriptional factors might change cell fate. Recent developments in reprogramming methods have shown that somatic cells can be directly reprogrammed to various kinds of neuronal cells directly. Moreover, overexpression of a neuron-specific transcriptional factor with a viral vector can change the fate of endogenous glial cells to neuronal cells in vivo. In this chapter, we discuss the advantages, issues, and possibility for clinical application of these reprogramming methods for cell transplantation/replacement therapy.

Original languageEnglish
Title of host publicationCell Therapy against Cerebral Stroke
Subtitle of host publicationComprehensive Reviews for Translational Researches and Clinical Trials
PublisherSpringer Japan
Number of pages8
ISBN (Electronic)9784431560593
ISBN (Print)9784431560579
Publication statusPublished - Jan 1 2017


  • Cerebral ischemia
  • In vivo direct reprogramming
  • Stroke
  • iNCs
  • iNSCs
  • iPSCs

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)


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