Abstract
The discovery of iPS indicated that overexpression of master transcriptional factors might change cell fate. Recent developments in reprogramming methods have shown that somatic cells can be directly reprogrammed to various kinds of neuronal cells directly. Moreover, overexpression of a neuron-specific transcriptional factor with a viral vector can change the fate of endogenous glial cells to neuronal cells in vivo. In this chapter, we discuss the advantages, issues, and possibility for clinical application of these reprogramming methods for cell transplantation/replacement therapy.
| Original language | English |
|---|---|
| Title of host publication | Cell Therapy against Cerebral Stroke |
| Subtitle of host publication | Comprehensive Reviews for Translational Researches and Clinical Trials |
| Publisher | Springer Japan |
| Pages | 39-46 |
| Number of pages | 8 |
| ISBN (Electronic) | 9784431560593 |
| ISBN (Print) | 9784431560579 |
| DOIs | |
| Publication status | Published - Jan 1 2017 |
Keywords
- Cerebral ischemia
- In vivo direct reprogramming
- Stroke
- iNCs
- iNSCs
- iPSCs
ASJC Scopus subject areas
- Medicine(all)
- Biochemistry, Genetics and Molecular Biology(all)