Iron-catalysed radical cyclization to synthesize germanium-substituted indolo[2,1-a]isoquinolin-6(5H)-ones and indolin-2-ones

Yani Luo; Tian Tian; Yasushi Nishihara; Leiyang Lv; Zhiping Li

doi:10.1039/d1cc03907e

Iron-catalysed radical cyclization to synthesize germanium-substituted indolo[2,1-a]isoquinolin-6(5H)-ones and indolin-2-ones

Yani Luo, Tian Tian, Yasushi Nishihara, Leiyang Lv, Zhiping Li

Research Institute for Interdisciplinary Science

Research output: Contribution to journal › Article › peer-review

24 Citations (Scopus)

Abstract

A simple and efficient strategy for iron-catalysed cascade radical cyclization was developed, by which an array of germanium-substituted indolo[2,1-a]isoquinolin-6(5H)-ones and indolin-2-ones were obtained in one pot with germanium hydrides as radical precursors. A rapid intramolecular radical trapping mode enabled the selective arylgermylation of alkenes over the prevalent hydrogermylation reaction.

Original language	English
Pages (from-to)	9276-9279
Number of pages	4
Journal	Chemical Communications
Volume	57
Issue number	73
DOIs	https://doi.org/10.1039/d1cc03907e
Publication status	Published - Sept 18 2021

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
Chemistry(all)
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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title = "Iron-catalysed radical cyclization to synthesize germanium-substituted indolo[2,1-a]isoquinolin-6(5H)-ones and indolin-2-ones",

abstract = "A simple and efficient strategy for iron-catalysed cascade radical cyclization was developed, by which an array of germanium-substituted indolo[2,1-a]isoquinolin-6(5H)-ones and indolin-2-ones were obtained in one pot with germanium hydrides as radical precursors. A rapid intramolecular radical trapping mode enabled the selective arylgermylation of alkenes over the prevalent hydrogermylation reaction.",

author = "Yani Luo and Tian Tian and Yasushi Nishihara and Leiyang Lv and Zhiping Li",

note = "Funding Information: We gratefully acknowledge the National Natural Science Foundation of China (22071266), the Fundamental Research Funds for the Central Universities, and the Research Funds of Renmin University of China (21XNLG04, 21XNH087). Publisher Copyright: {\textcopyright} The Royal Society of Chemistry 2021.",

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AU - Luo, Yani

AU - Tian, Tian

AU - Nishihara, Yasushi

AU - Lv, Leiyang

AU - Li, Zhiping

N1 - Funding Information: We gratefully acknowledge the National Natural Science Foundation of China (22071266), the Fundamental Research Funds for the Central Universities, and the Research Funds of Renmin University of China (21XNLG04, 21XNH087). Publisher Copyright: © The Royal Society of Chemistry 2021.

PY - 2021/9/18

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N2 - A simple and efficient strategy for iron-catalysed cascade radical cyclization was developed, by which an array of germanium-substituted indolo[2,1-a]isoquinolin-6(5H)-ones and indolin-2-ones were obtained in one pot with germanium hydrides as radical precursors. A rapid intramolecular radical trapping mode enabled the selective arylgermylation of alkenes over the prevalent hydrogermylation reaction.

AB - A simple and efficient strategy for iron-catalysed cascade radical cyclization was developed, by which an array of germanium-substituted indolo[2,1-a]isoquinolin-6(5H)-ones and indolin-2-ones were obtained in one pot with germanium hydrides as radical precursors. A rapid intramolecular radical trapping mode enabled the selective arylgermylation of alkenes over the prevalent hydrogermylation reaction.

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Iron-catalysed radical cyclization to synthesize germanium-substituted indolo[2,1-a]isoquinolin-6(5H)-ones and indolin-2-ones

Abstract

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