Iron-catalyzed C(sp2)-H bond functionalization with organoboron compounds

Rui Shang, Laurean Ilies, Sobi Asako, Eiichi Nakamura

    Research output: Contribution to journalArticlepeer-review

    145 Citations (Scopus)

    Abstract

    We report here that an iron-catalyzed directed C-H functionalization reaction allows the coupling of a variety of aromatic, heteroaromatic, and olefinic substrates with alkenyl and aryl boron compounds under mild oxidative conditions. We rationalize these results by the involvement of an organoiron(III) reactive intermediate that is responsible for the C-H bond-activation process. A zinc salt is crucial to promote the transfer of the organic group from the boron atom to the iron(III) atom.

    Original languageEnglish
    Pages (from-to)14349-14352
    Number of pages4
    JournalJournal of the American Chemical Society
    Volume136
    Issue number41
    DOIs
    Publication statusPublished - Oct 15 2014

    ASJC Scopus subject areas

    • Catalysis
    • General Chemistry
    • Biochemistry
    • Colloid and Surface Chemistry

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