Juvenile granulosa cell tumor with an unusual clinical course: A late-onset and late recurrent case

Thar Htet San; Yoko Ota; Soichiro Fushimi; Masayoshi Fujisawa; Hiroyuki Yanai; Hiroko Toda; Tadayoshi Kunitomo; Keisuke Kodama; Akihiro Matsukawa

Juvenile granulosa cell tumor with an unusual clinical course: A late-onset and late recurrent case

Thar Htet San, Yoko Ota, Soichiro Fushimi, Masayoshi Fujisawa, Hiroyuki Yanai, Hiroko Toda, Tadayoshi Kunitomo, Keisuke Kodama, Akihiro Matsukawa

Research output: Contribution to journal › Article › peer-review

Abstract

Juvenile granulosa cell tumors (JGCTs) are rare ovarian tumors with overall good prognoses. They differ from adult granulosa cell tumors (AGCTs), which are well known for late recurrence. Most JGCTs (~97%) occur in individuals <30 years old. We report a recurrent JGCT in a 40-year-old woman 5 years after initial presentation. The histological appearance and lack of 402C>G missense point mutation of FOXL2 gene (characteristic of AGCT but absent in JGCT) allowed differentiation from AGCT. This is the first comprehensive report of JGCT with late recurrence. Although rare, late recurrence of JGCT can occur; long-term surveillance is suggested.

Original language	English
Pages (from-to)	159-163
Number of pages	5
Journal	Acta medica Okayama
Volume	74
Issue number	2
Publication status	Published - 2020

Keywords

Adult granulosa cell tumor
Juvenile granulosa cell tumor
Late recurrence

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

Cite this

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title = "Juvenile granulosa cell tumor with an unusual clinical course: A late-onset and late recurrent case",

abstract = "Juvenile granulosa cell tumors (JGCTs) are rare ovarian tumors with overall good prognoses. They differ from adult granulosa cell tumors (AGCTs), which are well known for late recurrence. Most JGCTs (~97%) occur in individuals <30 years old. We report a recurrent JGCT in a 40-year-old woman 5 years after initial presentation. The histological appearance and lack of 402C>G missense point mutation of FOXL2 gene (characteristic of AGCT but absent in JGCT) allowed differentiation from AGCT. This is the first comprehensive report of JGCT with late recurrence. Although rare, late recurrence of JGCT can occur; long-term surveillance is suggested.",

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T1 - Juvenile granulosa cell tumor with an unusual clinical course

T2 - A late-onset and late recurrent case

AU - San, Thar Htet

AU - Ota, Yoko

AU - Fushimi, Soichiro

AU - Fujisawa, Masayoshi

AU - Yanai, Hiroyuki

AU - Toda, Hiroko

AU - Kunitomo, Tadayoshi

AU - Kodama, Keisuke

AU - Matsukawa, Akihiro

PY - 2020

Y1 - 2020

N2 - Juvenile granulosa cell tumors (JGCTs) are rare ovarian tumors with overall good prognoses. They differ from adult granulosa cell tumors (AGCTs), which are well known for late recurrence. Most JGCTs (~97%) occur in individuals <30 years old. We report a recurrent JGCT in a 40-year-old woman 5 years after initial presentation. The histological appearance and lack of 402C>G missense point mutation of FOXL2 gene (characteristic of AGCT but absent in JGCT) allowed differentiation from AGCT. This is the first comprehensive report of JGCT with late recurrence. Although rare, late recurrence of JGCT can occur; long-term surveillance is suggested.

AB - Juvenile granulosa cell tumors (JGCTs) are rare ovarian tumors with overall good prognoses. They differ from adult granulosa cell tumors (AGCTs), which are well known for late recurrence. Most JGCTs (~97%) occur in individuals <30 years old. We report a recurrent JGCT in a 40-year-old woman 5 years after initial presentation. The histological appearance and lack of 402C>G missense point mutation of FOXL2 gene (characteristic of AGCT but absent in JGCT) allowed differentiation from AGCT. This is the first comprehensive report of JGCT with late recurrence. Although rare, late recurrence of JGCT can occur; long-term surveillance is suggested.

KW - Adult granulosa cell tumor

KW - Juvenile granulosa cell tumor

KW - Late recurrence

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Juvenile granulosa cell tumor with an unusual clinical course: A late-onset and late recurrent case

Abstract

Keywords

ASJC Scopus subject areas

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