TY - JOUR
T1 - Ki-1+ Cutaneous Lymphoma
T2 - Gene Rearrangement Analysis of Tumor Cells in Tissue and Short-term Culture of a Patient
AU - Sugimoto, Higashi
AU - Nakayama, Fukiko
AU - Yamauchi, Takashi
AU - Tokura, Yoshiki
AU - Iwatsuki, Keiji
AU - Takigawa, Masahiro
AU - Yamada, Mizuho
AU - Maeda, Michiyuki
PY - 1988
Y1 - 1988
N2 - Cutaneous malignant lymphomas developed in an 80-year-old man without any evidence of leukemic disseminations of lymphoma cells. Immunohistologic staining showed the expression of Leu-3a, Leu-4, Ki-1, Tac, and HLA-DR antigens on tumor cells in tissue and large lymphoid cells in long-term, interleukin 2-containing culture of tumor explants. DNA samples extracted from the skin tumors and cultured lymphoid cells showed a clonal rearrangement of T-cell receptor (TCR) gene Cβ1 with the molecular size of 9 kilobases. These findings suggested the T-cell origin of Ki-1+ cutaneous lymphoma cells and the occurrence of a clonal proliferation of tumor cells in culture.
AB - Cutaneous malignant lymphomas developed in an 80-year-old man without any evidence of leukemic disseminations of lymphoma cells. Immunohistologic staining showed the expression of Leu-3a, Leu-4, Ki-1, Tac, and HLA-DR antigens on tumor cells in tissue and large lymphoid cells in long-term, interleukin 2-containing culture of tumor explants. DNA samples extracted from the skin tumors and cultured lymphoid cells showed a clonal rearrangement of T-cell receptor (TCR) gene Cβ1 with the molecular size of 9 kilobases. These findings suggested the T-cell origin of Ki-1+ cutaneous lymphoma cells and the occurrence of a clonal proliferation of tumor cells in culture.
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U2 - 10.1001/archderm.1988.01670030071025
DO - 10.1001/archderm.1988.01670030071025
M3 - Article
C2 - 2830849
SN - 2168-6068
VL - 124
SP - 405
EP - 408
JO - JAMA Dermatology
JF - JAMA Dermatology
IS - 3
ER -