Kimura's disease: Effects of age on clinical presentation

E. Kakehi, K. Kotani, Y. Otsuka, Y. Fukuyasu, Y. Hashimoto, S. Sakurai, A. Hirotani, K. Simizu, R. Fujita, K. Shoji, S. Adachi, M. Matsumura

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)


Background: Kimura's disease (KD) is known to be dominant among young Asian men, but it can also occur in middle- and advanced-aged people. The clinical characteristics of KD, especially by age, are not well known. Aim: This study was performed to investigate the effects of age on the clinical characteristics of KD. Design: We conducted a case series study. Methods: All case studies of patients diagnosed with KD were collected via a PubMed search of studies published until August 2018. The data were analyzed by age group. Results: In total, 215 studies were reviewed (238 patients; mean age of 36 years). The male:female ratio was 4:1 overall, 17:1 in patients aged <20 years, 4:1 in patients aged 20-39 years and 2:1 in patients aged ≥40 years (P = 0.01). The percentage of patients with pruritus was 15.4% overall, 3.8% in patients aged <20 years, 15.5% in patients aged 20-39 years and 21.7% in patients aged ≥40 years (P = 0.02). The time to diagnosis was 5.3 years overall, 3.2 years in patients aged <20 years, 4.7 years in patients aged 20-39 years and 7.1 years in patients aged ≥40 years (P < 0.01). Conclusions: The proportion of female patients affected the incidence of pruritus, and the time to diagnosis increased as the patients' age increased. There were no significant age-related differences in region/race, complications, multiplicity, laterality, anatomical distribution, maximum size, eosinophil count, immunoglobulin E level, initial treatment, recurrence or outcomes. This may be useful information for the diagnosis of KD.

Original languageEnglish
Pages (from-to)336-345
Number of pages10
Issue number5
Publication statusPublished - 2020
Externally publishedYes

ASJC Scopus subject areas

  • General Medicine


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