TY - JOUR
T1 - Kinetic evaluation of spin trapping rate constants of new CYPMPO-type spin traps for superoxide and other free radicals
AU - Sueishi, Yoshimi
AU - Kamogawa, Erisa
AU - Nakamura, Hideo
AU - Ukai, Mitsuko
AU - Kunieda, Michio
AU - Okada, Taiichi
AU - Shimmei, Masashi
AU - Kotake, Yashige
N1 - Funding Information:
Acknowledgement: This work was supported in part by a Grant-in-Aid for Science Research (C) (No. 25450169) from the Ministry of Education, Culture, Sports, Science, and Technology of Japan.
PY - 2015/3/1
Y1 - 2015/3/1
N2 - CYPMPO (5-(2,2-dimethyl-1,3-propoxyl cyclophosphoryl)-5-methyl-1- pyrroline N-oxide) is a phosphorus containing spin trap that has been useful in aqueous media. Using a kinetic ESR spin trapping technique, we evaluated free radical trapping rate constants of two newly synthesized CYPMPO-type spin traps, including 2,2-dibutyl-substituted CYPMPO (DBCYP) and 5-phenylsubstituted CYPMPO (PhCYP). We investigated the spin trapping of five free radical species, i. e., superoxide, hydroxyl radical, alkoxyl radical, alkyl peroxyl radical and methyl radical. Other than superoxide, spin trapping rate constants of DBCYP and PhCYP are comparable to CYPMPO, ranging from 43.9% to 101% of CYPMPO-fs corresponding rate constants. However, PhCYP-fs spin-trapping rate constant against superoxide was 44% higher than that of CYPMPO. The results indicate that DBCYP and PhCYP may be the spin traps as useful as CYPMPO either in aqueous or non-aqueous medium.
AB - CYPMPO (5-(2,2-dimethyl-1,3-propoxyl cyclophosphoryl)-5-methyl-1- pyrroline N-oxide) is a phosphorus containing spin trap that has been useful in aqueous media. Using a kinetic ESR spin trapping technique, we evaluated free radical trapping rate constants of two newly synthesized CYPMPO-type spin traps, including 2,2-dibutyl-substituted CYPMPO (DBCYP) and 5-phenylsubstituted CYPMPO (PhCYP). We investigated the spin trapping of five free radical species, i. e., superoxide, hydroxyl radical, alkoxyl radical, alkyl peroxyl radical and methyl radical. Other than superoxide, spin trapping rate constants of DBCYP and PhCYP are comparable to CYPMPO, ranging from 43.9% to 101% of CYPMPO-fs corresponding rate constants. However, PhCYP-fs spin-trapping rate constant against superoxide was 44% higher than that of CYPMPO. The results indicate that DBCYP and PhCYP may be the spin traps as useful as CYPMPO either in aqueous or non-aqueous medium.
KW - CYPMPO Derivatives
KW - Spin Trapping
KW - Spin Trapping Rate Constant
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U2 - 10.1515/zpch-2014-0610
DO - 10.1515/zpch-2014-0610
M3 - Article
AN - SCOPUS:84929088286
SN - 0942-9352
VL - 229
SP - 317
EP - 326
JO - Zeitschrift fur Physikalische Chemie
JF - Zeitschrift fur Physikalische Chemie
IS - 3
ER -