Kinetic resolution of secondary alcohols by the combination of a chiral Brønsted acid, DABCO, and acetyl chloride

Hiroki Mandai; Kyouta Murota; Koichi Mitsudo; Seiji Suga

doi:10.1021/ol301373x

Kinetic resolution of secondary alcohols by the combination of a chiral Brønsted acid, DABCO, and acetyl chloride

Hiroki Mandai, Kyouta Murota, Koichi Mitsudo, Seiji Suga

Research output: Contribution to journal › Article › peer-review

36 Citations (Scopus)

Abstract

An efficient and simple protocol for the kinetic resolution of secondary alcohols is presented. The new system is based on a combination of chiral Brønsted acid, DABCO, and acetyl chloride and gives various enantioenriched alcohols with selectivity factors up to 105.

Original language	English
Pages (from-to)	3486-3489
Number of pages	4
Journal	Organic Letters
Volume	14
Issue number	13
DOIs	https://doi.org/10.1021/ol301373x
Publication status	Published - Jul 6 2012

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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10.1021/ol301373x

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title = "Kinetic resolution of secondary alcohols by the combination of a chiral Br{\o}nsted acid, DABCO, and acetyl chloride",

abstract = "An efficient and simple protocol for the kinetic resolution of secondary alcohols is presented. The new system is based on a combination of chiral Br{\o}nsted acid, DABCO, and acetyl chloride and gives various enantioenriched alcohols with selectivity factors up to 105.",

author = "Hiroki Mandai and Kyouta Murota and Koichi Mitsudo and Seiji Suga",

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AU - Mandai, Hiroki

AU - Murota, Kyouta

AU - Mitsudo, Koichi

AU - Suga, Seiji

PY - 2012/7/6

Y1 - 2012/7/6

N2 - An efficient and simple protocol for the kinetic resolution of secondary alcohols is presented. The new system is based on a combination of chiral Brønsted acid, DABCO, and acetyl chloride and gives various enantioenriched alcohols with selectivity factors up to 105.

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JO - Organic Letters

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Kinetic resolution of secondary alcohols by the combination of a chiral Brønsted acid, DABCO, and acetyl chloride

Abstract

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