Label-free detection of low-molecular-weight samples using a terahertz chemical microscope

Takuya Kuwana, Masahiro Ogawa, Kenji Sakai, Toshihiko Kiwa, Keiji Tsukada

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)


A terahertz chemical microscope (TCM) has been proposed and developed to visualize the distribution of biomolecular interactions on a sensing plate without any labels. In this study, the concanavalin A (Con A)-D-(+)-mannose (mannose) interaction was detected using the TCM with mannose applied as the analyte and Con A immobilized on the sensing plate. To demonstrate this interaction, the amplitude of terahertz pulses as a function of Con A-mannose interaction time, as well as the Con A-mannose coupling concentration, was evaluated. The results suggest that coupling kinetics may be evaluated using a TCM.

Original languageEnglish
Article number42401
Pages (from-to)42401
JournalApplied Physics Express
Issue number4
Publication statusPublished - Mar 14 2016

ASJC Scopus subject areas

  • Engineering(all)
  • Physics and Astronomy(all)


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