Lactobacillus-mediated RNA interference in nematode

Ai Kuwahara, Masashi Arita, Akira Kushiro, Yasuji Sakube, Masahiko Sisido, Takashi Ohtsuki

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)


We engineered Lactobacillus paracasei to produce a dsRNA that would trigger RNAi-induced silencing of an essential gene in the nematode Caenorhabditis elegans. The dsRNA-expressing L. paracasei can be used in experiments conducted on culture plates and may also be used as an orally administrable dsRNA carrier for humans and other mammals.

Original languageEnglish
Pages (from-to)189-192
Number of pages4
JournalJournal of Bioscience and Bioengineering
Issue number2
Publication statusPublished - Feb 2010


  • Caenorhabditis elegans
  • Lactic acid bacteria
  • Lactobacillus paracasei
  • Nematode
  • RNAi
  • dsRNA

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Applied Microbiology and Biotechnology


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