Abstract
Manipulation of magnetic nanoparticles (MNP) by an external magnetic
field has been widely studied in the fields of biotechnology and
medicine for collecting and/or reacting biomaterials in the solutions.
Here, dynamic behaviors of MNP in solution under changing gradient
magnetic field were investigated using our newly developed laser
transmission system (LTS) with a variable magnetic field manipulator.
The manipulator consists of a moving permanent magnet placed beside the
optical cell filled with MNP solution. A laser beam was focused on the
cell and the transmitted laser beam was detected by a silicon
photodiode, so that the localized concentration of the MNP at the
focused area could be evaluated by the intensity of transmitted laser
beam. In this study, the LTS was applied to evaluate dynamic behaviors
of MNP in serum solution. Dispersion and aggregation of MNP in the
solution were evaluated. While time evolution of dispersion depends on
the serum concentration, the behavior during aggregation by the magnetic
field was independent of the serum concentration. A series of
measurements for zeta-potentials, distributions of particle size, and
magnetization distributions was carried out to understand this
difference in the behavior. The results indicated that a Brownian motion
was main force to distribute the MNP in the solution; on the other hand,
the magnetic force to the MNP mainly affected the behavior during
aggregation of the MNP in the solution.
Original language | English |
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Pages (from-to) | 15025 |
Journal | AIP Advances |
Volume | 10 |
Issue number | 1 |
DOIs | |
Publication status | Published - Jan 1 2020 |
Externally published | Yes |