Lethal biliary congestive acute hepatitis e without acute liver failure: A case report

Nao Yamauchi, Tetsuya Yasunaka, Akinobu Takaki, Yoshimune Hinami, Masaru Kinomura, Akina Kawahara, Takuya Adachi, Atsushi Oyama, Nozomu Wada, Yasuto Takeuchi, Hideki Onishi, Hidenori Shiraha, Hiroyuki Okada

Research output: Contribution to journalArticlepeer-review


A 64-year-old man in whom benign hyperbilirubinemia had been identified was found to suffer from acute hepatitis E. Laboratory examination of the patient revealed high transaminase levels and hyperbilirubinemia, suggesting acute hepatitis, while the prothrombin time was within the normal range. The transaminase levels decreased and prothrombin time remained within the normal range; however, hyperbilirubinemia worsened to 39 mg/dl. The patient developed the complications of acute renal failure and sepsis, and eventually died. An autopsy was performed that showed no liver atrophy, liver fibrosis progression, or massive necrosis. The lung and kidney were revealed to be positive for fungal infection. The kidney was revealed to exhibit tubular conges-tion with bile. The present case offers information on the clinical course of acute hepatitis E in relatively elderly patients.

Original languageEnglish
Pages (from-to)463-470
Number of pages8
JournalActa Hepatologica Japonica
Issue number8
Publication statusPublished - 2021


  • Acute hepatitis
  • Acute liver failure
  • Constitutional jaundice
  • Hepatitis E jaundice

ASJC Scopus subject areas

  • Hepatology


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