Ligands with dual vitamin D3-agonistic and androgen-antagonistic activities

Shinnosuke Hosoda; Aya Tanatani; Ken Ichi Wakabayashi; Yusuke Nakano; Hiroyuki Miyachi; Kazuo Nagasawa; Yuichi Hashimoto

doi:10.1016/j.bmcl.2005.06.044

Ligands with dual vitamin D₃-agonistic and androgen-antagonistic activities

Shinnosuke Hosoda, Aya Tanatani, Ken Ichi Wakabayashi, Yusuke Nakano, Hiroyuki Miyachi, Kazuo Nagasawa, Yuichi Hashimoto

Research output: Contribution to journal › Article › peer-review

42 Citations (Scopus)

Abstract

Ligands possessing dual vitamin D₃-agonistic (estimated as HL-60 monocytic cell differentiation induction) and androgen-antagonistic (estimated as testosterone-induced SC-3 cell growth inhibition) activities with various activity spectra were prepared based on a substituted bis-phenylmethane skeleton. Some of them were revealed to be potent androgen antagonists with a nonsecosteroidal vitamin D₃ skeleton.

Original language	English
Pages (from-to)	4327-4331
Number of pages	5
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	15
Issue number	19
DOIs	https://doi.org/10.1016/j.bmcl.2005.06.044
Publication status	Published - Oct 1 2005
Externally published	Yes

Keywords

Androgen antagonist
Bisphenylmethane
Vitamin D

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

Access to Document

10.1016/j.bmcl.2005.06.044

Cite this

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title = "Ligands with dual vitamin D3-agonistic and androgen-antagonistic activities",

abstract = "Ligands possessing dual vitamin D3-agonistic (estimated as HL-60 monocytic cell differentiation induction) and androgen-antagonistic (estimated as testosterone-induced SC-3 cell growth inhibition) activities with various activity spectra were prepared based on a substituted bis-phenylmethane skeleton. Some of them were revealed to be potent androgen antagonists with a nonsecosteroidal vitamin D3 skeleton.",

keywords = "Androgen antagonist, Bisphenylmethane, Vitamin D",

author = "Shinnosuke Hosoda and Aya Tanatani and Wakabayashi, {Ken Ichi} and Yusuke Nakano and Hiroyuki Miyachi and Kazuo Nagasawa and Yuichi Hashimoto",

note = "Funding Information: The work described in this paper was partially supported by Grants-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology, Japan, and the Japan Society for the Promotion of Science, the Mochida Memorial Foundation, and the Uehara Memorial Foundation for Medical and Pharmaceutical Research.",

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T1 - Ligands with dual vitamin D3-agonistic and androgen-antagonistic activities

AU - Hosoda, Shinnosuke

AU - Tanatani, Aya

AU - Wakabayashi, Ken Ichi

AU - Nakano, Yusuke

AU - Miyachi, Hiroyuki

AU - Nagasawa, Kazuo

AU - Hashimoto, Yuichi

N1 - Funding Information: The work described in this paper was partially supported by Grants-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology, Japan, and the Japan Society for the Promotion of Science, the Mochida Memorial Foundation, and the Uehara Memorial Foundation for Medical and Pharmaceutical Research.

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KW - Bisphenylmethane

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