Limonene inhalation reduces allergic airway inflammation in Dermatophagoides farinae-treated mice

Ryoji Hirota, Hiroyuki Nakamura, Sabah Asif Bhatti, Nlandu Roger Ngatu, Basilua Andre Muzembo, Narongpon Dumavibhat, Masamitsu Eitoku, Masayoshi Sawamura, Narufumi Suganuma

Research output: Contribution to journalArticlepeer-review

41 Citations (Scopus)


Limonene is one of the main flavonoids which is reported to inhibit the inflammatory response by suppressing the production of reactive oxygen species. The aim of this study was to evaluate whether limonene can inhibit Dermatophagoides farinae-induced airway hyperresponsiveness (AHR), eosinophilic infiltration and other histological changes in the lung, T helper (Th) 2 cytokine production and airway remodeling in a mice model of asthma. Treatment with limonene significantly reduced the levels of IL-5, IL-13, eotaxin, MCP-1, and TGF-β1 in bronchoalveolar lavage fluid. The goblet cell metaplasia, thickness of airway smooth muscle, and airway fibrosis were markedly decreased in limonene-treated mice. Furthermore, AHR to acetylcholine was significantly abrogated in limonene-treated mice. These results indicate that limonene has a potential to reduce airway remodeling and AHR in asthma model.

Original languageEnglish
Pages (from-to)373-381
Number of pages9
JournalInhalation Toxicology
Issue number6
Publication statusPublished - May 2012
Externally publishedYes


  • Airway inflammation
  • Asthma
  • Dermatophagoides farinae
  • Limonene
  • Th2 cytokine

ASJC Scopus subject areas

  • Toxicology
  • Health, Toxicology and Mutagenesis


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