TY - JOUR
T1 - Limonene inhalation reduces allergic airway inflammation in Dermatophagoides farinae-treated mice
AU - Hirota, Ryoji
AU - Nakamura, Hiroyuki
AU - Bhatti, Sabah Asif
AU - Ngatu, Nlandu Roger
AU - Muzembo, Basilua Andre
AU - Dumavibhat, Narongpon
AU - Eitoku, Masamitsu
AU - Sawamura, Masayoshi
AU - Suganuma, Narufumi
N1 - Funding Information:
This study was supported by a grant from the Japanese Ministry of Economy. The authors declared no conflict of interest.
PY - 2012/5
Y1 - 2012/5
N2 - Limonene is one of the main flavonoids which is reported to inhibit the inflammatory response by suppressing the production of reactive oxygen species. The aim of this study was to evaluate whether limonene can inhibit Dermatophagoides farinae-induced airway hyperresponsiveness (AHR), eosinophilic infiltration and other histological changes in the lung, T helper (Th) 2 cytokine production and airway remodeling in a mice model of asthma. Treatment with limonene significantly reduced the levels of IL-5, IL-13, eotaxin, MCP-1, and TGF-β1 in bronchoalveolar lavage fluid. The goblet cell metaplasia, thickness of airway smooth muscle, and airway fibrosis were markedly decreased in limonene-treated mice. Furthermore, AHR to acetylcholine was significantly abrogated in limonene-treated mice. These results indicate that limonene has a potential to reduce airway remodeling and AHR in asthma model.
AB - Limonene is one of the main flavonoids which is reported to inhibit the inflammatory response by suppressing the production of reactive oxygen species. The aim of this study was to evaluate whether limonene can inhibit Dermatophagoides farinae-induced airway hyperresponsiveness (AHR), eosinophilic infiltration and other histological changes in the lung, T helper (Th) 2 cytokine production and airway remodeling in a mice model of asthma. Treatment with limonene significantly reduced the levels of IL-5, IL-13, eotaxin, MCP-1, and TGF-β1 in bronchoalveolar lavage fluid. The goblet cell metaplasia, thickness of airway smooth muscle, and airway fibrosis were markedly decreased in limonene-treated mice. Furthermore, AHR to acetylcholine was significantly abrogated in limonene-treated mice. These results indicate that limonene has a potential to reduce airway remodeling and AHR in asthma model.
KW - Airway inflammation
KW - Asthma
KW - Dermatophagoides farinae
KW - Limonene
KW - Th2 cytokine
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U2 - 10.3109/08958378.2012.675528
DO - 10.3109/08958378.2012.675528
M3 - Article
C2 - 22564095
AN - SCOPUS:84860878060
SN - 0895-8378
VL - 24
SP - 373
EP - 381
JO - Inhalation Toxicology
JF - Inhalation Toxicology
IS - 6
ER -