Linkage mapping of the locus responsible for male pseudohermaphroditism (mp) on rat chromosome 7

Yasuhiro Kawai; Yuriko Takeno; Eiji Kobayashi; Motokazu Tachibana; Yasumasa Wakafuji; Junko Noguchi; Tetsuo Kunieda

doi:10.1538/expanim.53.379

Linkage mapping of the locus responsible for male pseudohermaphroditism (mp) on rat chromosome 7

Yasuhiro Kawai, Yuriko Takeno, Eiji Kobayashi, Motokazu Tachibana, Yasumasa Wakafuji, Junko Noguchi, Tetsuo Kunieda

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

TF is a mutant rat strain showing male pseudohermaphroditism controlled by an autosomal single recessive gene (mp). The affected rats show lack of Leydig cells and androgen deficiency. In this study, we performed linkage analysis using F₂ progeny of crosses between TF and BN strains to determine the chromosomal localization of the mp locus. The mp locus was mapped in a 4 cM region of the distal region of rat chromosome 7 between D7Rat3 and D7Rat115 or D7Rat94. Comparison of the linkage map with corresponding regions of the published rat genome sequence revealed several candidate genes for the mp mutation, including the Dhh, Tegt, Gdp3, and Amhr2 genes.

Original language	English
Pages (from-to)	379-382
Number of pages	4
Journal	Experimental Animals
Volume	53
Issue number	4
DOIs	https://doi.org/10.1538/expanim.53.379
Publication status	Published - 2004

Keywords

Androgen deficiency
Leydig cell
Male pseudohermaphroditism

ASJC Scopus subject areas

Animal Science and Zoology
Biochemistry, Genetics and Molecular Biology(all)
veterinary(all)

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10.1538/expanim.53.379

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abstract = "TF is a mutant rat strain showing male pseudohermaphroditism controlled by an autosomal single recessive gene (mp). The affected rats show lack of Leydig cells and androgen deficiency. In this study, we performed linkage analysis using F2 progeny of crosses between TF and BN strains to determine the chromosomal localization of the mp locus. The mp locus was mapped in a 4 cM region of the distal region of rat chromosome 7 between D7Rat3 and D7Rat115 or D7Rat94. Comparison of the linkage map with corresponding regions of the published rat genome sequence revealed several candidate genes for the mp mutation, including the Dhh, Tegt, Gdp3, and Amhr2 genes.",

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AU - Kawai, Yasuhiro

AU - Takeno, Yuriko

AU - Kobayashi, Eiji

AU - Tachibana, Motokazu

AU - Wakafuji, Yasumasa

AU - Noguchi, Junko

AU - Kunieda, Tetsuo

PY - 2004

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AB - TF is a mutant rat strain showing male pseudohermaphroditism controlled by an autosomal single recessive gene (mp). The affected rats show lack of Leydig cells and androgen deficiency. In this study, we performed linkage analysis using F2 progeny of crosses between TF and BN strains to determine the chromosomal localization of the mp locus. The mp locus was mapped in a 4 cM region of the distal region of rat chromosome 7 between D7Rat3 and D7Rat115 or D7Rat94. Comparison of the linkage map with corresponding regions of the published rat genome sequence revealed several candidate genes for the mp mutation, including the Dhh, Tegt, Gdp3, and Amhr2 genes.

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Linkage mapping of the locus responsible for male pseudohermaphroditism (mp) on rat chromosome 7

Abstract

Keywords

ASJC Scopus subject areas

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