Linking cortical circuit models to human cognition with laminar fMRI

Jiajia Yang, Laurentius Huber, Yinghua Yu, Peter A. Bandettini

Research output: Contribution to journalReview articlepeer-review

10 Citations (Scopus)


Laboratory animal research has provided significant knowledge into the function of cortical circuits at the laminar level, which has yet to be fully leveraged towards insights about human brain function on a similar spatiotemporal scale. The use of functional magnetic resonance imaging (fMRI) in conjunction with neural models provides new opportunities to gain important insights from current knowledge. During the last five years, human studies have demonstrated the value of high-resolution fMRI to study laminar-specific activity in the human brain. This is mostly performed at ultra-high-field strengths (≥ 7 T) and is known as laminar fMRI. Advancements in laminar fMRI are beginning to open new possibilities for studying questions in basic cognitive neuroscience. In this paper, we first review recent methodological advances in laminar fMRI and describe recent human laminar fMRI studies. Then, we discuss how the use of laminar fMRI can help bridge the gap between cortical circuit models and human cognition.

Original languageEnglish
Pages (from-to)467-478
Number of pages12
JournalNeuroscience and Biobehavioral Reviews
Publication statusPublished - Sept 2021


  • Cognition
  • Cortical circuit models
  • Cortical layers
  • Human brain function
  • Laminar fMRI

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Cognitive Neuroscience
  • Behavioral Neuroscience


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