@article{ab87171afa884b93a08b80e5cce964c5,
title = "Lipase-catalyzed efficient kinetic resolution of 3-Hydroxy-3-(pentafluorophenyl)propionitrile",
abstract = "Efficient kinetic resolution of racemic 3-hydroxy-3-(pentafluorophenyl)- propionitrile (±)-1 by a lipase-catalyzed transesterification gave optically pure (S)-3-hydroxy-3-(pentafluorophenyl-)propionitrile (S)-1 and (R)-(+)-3-acetoxy-3-(penta-fluorophenyl)propionitrile (R)-1 [>99% ee, respectively, E = 1057], the former of which was further transformed into (S)-(-)-3-amino-1-(pentafluorophenyl)-1-propanol (S)-7 in four steps.",
author = "Takashi Sakal and Tetsuo Takayama and Takafumi Ohkawa and Osamu Yoshio and Tadashi Ema and Masanori Utaka",
note = "Funding Information: Acknowledgment: This work was partially supported by a Grant-in-Aid for Scientific Research (B, No. 07455362; C, No. 06650985) from the Ministry of Education, Science and Culture of Japan. We are grateful to Amano Pharmaceutical Co., Ltd., TOYOBOCo., Ltd. and Sumitomo Chemical Co., Ltd. for kind supply of the lipases and to the SC-NMR laboratory of Okayama University for 19F N\]VIR( 188 MHz) and ~H NMR (500 and 200 MHz) analyses.",
year = "1997",
month = mar,
day = "17",
doi = "10.1016/S0040-4039(97)00255-4",
language = "English",
volume = "38",
pages = "1987--1990",
journal = "Tetrahedron Letters",
issn = "0040-4039",
publisher = "Elsevier Limited",
number = "11",
}