Liquid phase deposited titania coating to enable in vitro apatite formation on Ti6Al4V alloy

Satoshi Hayakawa, Yoshitake Masuda, Keigo Okamoto, Yuki Shirosaki, Kazumi Kato, Akiyoshi Osaka

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)


A recently developed "GRAPE® technology" provides titanium or titanium alloy implants with spontaneous apatite-forming ability in vitro, which requires properly designed gaps and optimum heat treatment in air. In this study, titanium alloy and commercially pure (cp) titanium substrates were thermally oxidized in air before aligning pairs of specimens in the GRAPE® set-up, i.e., titanium alloy and cp titanium substrates were aligned parallel to each other with optimum gap width (spatial design). A liquid phase deposition (LPD) technique was employed for titania coatings on titanium alloy substrate. Then, they were soaked in Kokubo's simulated body fluid (SBF, pH 7.4, 36.5 C) for 7 days to confirm the in vitro apatite formation on the substrates under the specific spatial design. Anatase-type titania coatings fabricated by using LPD technique led to the deposition of apatite particles within 7 days and showed apatite X-ray diffraction. On the other hand, thermally oxidized titanium alloy substrate in air and non-treated specimens did not show any apatite X-ray diffraction. These results indicated that the heterogeneous nucleation of apatite induced on anatase-type titania coating prepared by LPD technique when it was aligned parallel to thermally oxidized cp titanium substrate with optimum gap width.

Original languageEnglish
Pages (from-to)375-381
Number of pages7
JournalJournal of Materials Science: Materials in Medicine
Issue number2
Publication statusPublished - Feb 2014

ASJC Scopus subject areas

  • Biophysics
  • Bioengineering
  • Biomaterials
  • Biomedical Engineering


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