TY - JOUR
T1 - Localization of advanced glycation endproducts in the kidney of experimental diabetic rats
AU - Shikata, Kenichi
AU - Makino, Hirofumi
AU - Sugimoto, Hikaru
AU - Kushiro, Masahiko
AU - Ota, Kosuke
AU - Akiyama, Kenji
AU - Araki, Norie
AU - Horiuchi, Seikoh
AU - Ota, Zensuke
N1 - Funding Information:
This was supported by a Grant-in Aid for Scientific Research (C-04671481) from the Ministry of Education, Science and Culture of Japan to Dr. H. Makino.
PY - 1995
Y1 - 1995
N2 - Advanced glycation endproducts (AGE) have been proposed as a major mediator in the development of various diabetic complications. In order to evaluate the involvement of AGE in the development of diabetic nephropathy, we examined the localization of AGE in the kidney of the streptozotocin-induced diabetic rats immunohistochemically using a monoclonal antibody directed to AGE. In the diabetic rats, glomerular hypertrophy, thickening of the glomerular basement membrane, and expansion of mesangial matrix were observed. AGE was detected in expanded mesangial area and glomerular basement membrane in the kidneys of diabetic rats. The present results suggest that AGE may participate in the development of diabetic nephropathy.
AB - Advanced glycation endproducts (AGE) have been proposed as a major mediator in the development of various diabetic complications. In order to evaluate the involvement of AGE in the development of diabetic nephropathy, we examined the localization of AGE in the kidney of the streptozotocin-induced diabetic rats immunohistochemically using a monoclonal antibody directed to AGE. In the diabetic rats, glomerular hypertrophy, thickening of the glomerular basement membrane, and expansion of mesangial matrix were observed. AGE was detected in expanded mesangial area and glomerular basement membrane in the kidneys of diabetic rats. The present results suggest that AGE may participate in the development of diabetic nephropathy.
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U2 - 10.1016/1056-8727(95)80019-B
DO - 10.1016/1056-8727(95)80019-B
M3 - Article
C2 - 8573744
AN - SCOPUS:0028791830
SN - 1056-8727
VL - 9
SP - 269
EP - 271
JO - Journal of Diabetes and Its Complications
JF - Journal of Diabetes and Its Complications
IS - 4
ER -
