Localization of advanced glycation endproducts in the kidney of experimental diabetic rats

Kenichi Shikata, Hirofumi Makino, Hikaru Sugimoto, Masahiko Kushiro, Kosuke Ota, Kenji Akiyama, Norie Araki, Seikoh Horiuchi, Zensuke Ota

Research output: Contribution to journalArticlepeer-review

21 Citations (Scopus)


Advanced glycation endproducts (AGE) have been proposed as a major mediator in the development of various diabetic complications. In order to evaluate the involvement of AGE in the development of diabetic nephropathy, we examined the localization of AGE in the kidney of the streptozotocin-induced diabetic rats immunohistochemically using a monoclonal antibody directed to AGE. In the diabetic rats, glomerular hypertrophy, thickening of the glomerular basement membrane, and expansion of mesangial matrix were observed. AGE was detected in expanded mesangial area and glomerular basement membrane in the kidneys of diabetic rats. The present results suggest that AGE may participate in the development of diabetic nephropathy.

Original languageEnglish
Pages (from-to)269-271
Number of pages3
JournalJournal of Diabetes and Its Complications
Issue number4
Publication statusPublished - 1995

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology


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