Localization of FGFR-1 in axotomized and peripheral nerve transplanted ferret retina

Mei Zi Quan; Mitsuko Kosaka; Masami Watanabe; Yutaka Fukuda

doi:10.1097/00001756-199912160-00033

Localization of FGFR-1 in axotomized and peripheral nerve transplanted ferret retina

Mei Zi Quan, Mitsuko Kosaka, Masami Watanabe, Yutaka Fukuda

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

RETINAL ganglion cells (RGCs) survive axotomy and regenerate their axons into the peripheral nerve graft in adult mammals. To understand the potential role of fibroblast growth factors (FGFs) in survival and regeneration of axotomized RGCs, we examined FGF receptor 1 (FGFR-1) localization in normal and PN grafted ferret retinas by immunohistochemistry in combination with retrograde labeling. Prominent expression of FGFR-1 was observed in outer plexiform layer and ganglion cell layer of normal ferret retina. In the ganglion cell layer, FGFR-1 immunoreactivity was detected in about 30% of RGCs, predominantly in large cells. In the PN grafted ferret retina, 90% of RGCs with regenerated axons expressed FGFR-1. Our findings suggest that FGFs may play an important role in the survival and axonal regeneration of RGCs of adult mammals.

Original language	English
Pages (from-to)	3903-3907
Number of pages	5
Journal	NeuroReport
Volume	10
Issue number	18
DOIs	https://doi.org/10.1097/00001756-199912160-00033
Publication status	Published - Dec 16 1999
Externally published	Yes

Keywords

Axonal regeneration
FGFR-1
Ferret
Peripheral nerve transplantation
RGC

ASJC Scopus subject areas

Neuroscience(all)

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10.1097/00001756-199912160-00033

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title = "Localization of FGFR-1 in axotomized and peripheral nerve transplanted ferret retina",

abstract = "RETINAL ganglion cells (RGCs) survive axotomy and regenerate their axons into the peripheral nerve graft in adult mammals. To understand the potential role of fibroblast growth factors (FGFs) in survival and regeneration of axotomized RGCs, we examined FGF receptor 1 (FGFR-1) localization in normal and PN grafted ferret retinas by immunohistochemistry in combination with retrograde labeling. Prominent expression of FGFR-1 was observed in outer plexiform layer and ganglion cell layer of normal ferret retina. In the ganglion cell layer, FGFR-1 immunoreactivity was detected in about 30% of RGCs, predominantly in large cells. In the PN grafted ferret retina, 90% of RGCs with regenerated axons expressed FGFR-1. Our findings suggest that FGFs may play an important role in the survival and axonal regeneration of RGCs of adult mammals.",

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author = "Quan, {Mei Zi} and Mitsuko Kosaka and Masami Watanabe and Yutaka Fukuda",

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T1 - Localization of FGFR-1 in axotomized and peripheral nerve transplanted ferret retina

AU - Quan, Mei Zi

AU - Kosaka, Mitsuko

AU - Watanabe, Masami

AU - Fukuda, Yutaka

PY - 1999/12/16

Y1 - 1999/12/16

N2 - RETINAL ganglion cells (RGCs) survive axotomy and regenerate their axons into the peripheral nerve graft in adult mammals. To understand the potential role of fibroblast growth factors (FGFs) in survival and regeneration of axotomized RGCs, we examined FGF receptor 1 (FGFR-1) localization in normal and PN grafted ferret retinas by immunohistochemistry in combination with retrograde labeling. Prominent expression of FGFR-1 was observed in outer plexiform layer and ganglion cell layer of normal ferret retina. In the ganglion cell layer, FGFR-1 immunoreactivity was detected in about 30% of RGCs, predominantly in large cells. In the PN grafted ferret retina, 90% of RGCs with regenerated axons expressed FGFR-1. Our findings suggest that FGFs may play an important role in the survival and axonal regeneration of RGCs of adult mammals.

AB - RETINAL ganglion cells (RGCs) survive axotomy and regenerate their axons into the peripheral nerve graft in adult mammals. To understand the potential role of fibroblast growth factors (FGFs) in survival and regeneration of axotomized RGCs, we examined FGF receptor 1 (FGFR-1) localization in normal and PN grafted ferret retinas by immunohistochemistry in combination with retrograde labeling. Prominent expression of FGFR-1 was observed in outer plexiform layer and ganglion cell layer of normal ferret retina. In the ganglion cell layer, FGFR-1 immunoreactivity was detected in about 30% of RGCs, predominantly in large cells. In the PN grafted ferret retina, 90% of RGCs with regenerated axons expressed FGFR-1. Our findings suggest that FGFs may play an important role in the survival and axonal regeneration of RGCs of adult mammals.

KW - Axonal regeneration

KW - FGFR-1

KW - Ferret

KW - Peripheral nerve transplantation

KW - RGC

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ER -

Localization of FGFR-1 in axotomized and peripheral nerve transplanted ferret retina

Abstract

Keywords

ASJC Scopus subject areas

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