Long-term observation of osteomalacia caused by adefovir-induced fanconi's syndrome

Tomohiro Terasaka, Eijiro Ueta, Hirotaka Ebara, Koichi Waseda, Yoshihisa Hanayama, Akinobu Takaki, Tomoko Kawabata, Hitoshi Sugiyama, Ko Hidani, Fumio Otsuka

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)


A 64-year-old man suffering polyarthralgia and bone pain was referred to our hospital. Renal dysfunction, hypophosphatemia and increased levels of bone alkaline phosphatase were found. The patient's serum creatinine level had gradually increased after the initiation of adefovir dipivoxil administration for hepatitis B. In agreement with multifocal uptakes of bone scintigraphy, iliac bone biopsy revealed an abnormal increase in osteoid tissues. Reducing the dose of adefovir and initiating the administration of eldecalcitol were effective for reducing proteinuria and glucosuria, and for ameliorating bone pain with an increase in serum phosphate level. This case first showed a clinical course of hypophosphatemic osteomalacia caused by secondary Fanconi's syndrome for 8 years after adefovir administration. Early diagnosis is important for the reversibility of bone damage and for a better renal prognosis.

Original languageEnglish
Pages (from-to)53-56
Number of pages4
JournalActa medica Okayama
Issue number1
Publication statusPublished - 2014


  • Adefovir dipivoxil (ADV)
  • Eldecalcitol
  • Fanconi's syndrome
  • Hypophosphatemia
  • Osteomalacia

ASJC Scopus subject areas

  • General Biochemistry,Genetics and Molecular Biology


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