Long-term outcomes of endoscopic submucosal dissection for early gastric cancer: a multicenter collaborative study

Satoshi Tanabe, Kenji Ishido, Takayuki Matsumoto, Takashi Kosaka, Ichiro Oda, Haruhisa Suzuki, Junko Fujisaki, Hiroyuki Ono, Noboru Kawata, Tsuneo Oyama, Akiko Takahashi, Hisashi Doyama, Masaaki Kobayashi, Noriya Uedo, Kenta Hamada, Takashi Toyonaga, Fumiaki Kawara, Shinji Tanaka, Yoshikazu Yoshifuku

Research output: Contribution to journalArticlepeer-review

88 Citations (Scopus)


Objective: The indications for endoscopic submucosal dissection (ESD) in patients with early gastric cancer (EGC) have been expanded. However, the long-term outcomes of ESD remain unclear. We retrospectively investigated the long-term outcomes of ESD in patients with EGC. Methods: We retrospectively studied patients with EGC who underwent ESD at 11 institutions between January 2003 and December 2010. A total of 6456 patients (7979 lesions) who met the absolute indications for ESD and 4202 patients (5781 lesions) who met the expanded indications for ESD were studied. Clinicopathological features, clinical course, and outcomes were studied in 67 patients in whom local recurrence or metastatic recurrence was diagnosed as of March 31, 2014. The median follow-up period was 56 months. Results: Local recurrence was diagnosed in 14 patients (0.22%) who met the absolute indications and 53 patients (1.26%) who met the expanded indications. The rate of local recurrence was significantly higher in patients with expanded-indication lesions (p < 0.05). As additional treatment for recurrence, most patients received endoscopic treatment. Metastatic recurrence did not develop in any patient with absolute-indication lesions, but was diagnosed in 6 patients (0.14%) with expanded-indication lesions (p < 0.05). The histological type was undifferentiated mixed type in half the patients. Three patients died of primary gastric cancer. Conclusions: ESD for expanded-indication lesions of EGC is considered an effective therapy associated with an extremely low rate of metastatic recurrence on long-term follow-up. However, fully informed consent concerning the risk of metastatic recurrence should be obtained before ESD, and close postoperative follow-up is essential.

Original languageEnglish
Pages (from-to)45-52
Number of pages8
JournalGastric Cancer
Publication statusPublished - Mar 1 2017
Externally publishedYes


  • Absolute-indication lesions
  • ESD
  • Early gastric cancer
  • Expanded-indication lesions
  • Outcomes

ASJC Scopus subject areas

  • Oncology
  • Gastroenterology
  • Cancer Research


Dive into the research topics of 'Long-term outcomes of endoscopic submucosal dissection for early gastric cancer: a multicenter collaborative study'. Together they form a unique fingerprint.

Cite this