Long-term parvovirus B19 infections with genetic drift after cord blood transplantation complicated by persistent CD4+ lymphocytopenia

Michio Suzuki; Yoshinori Ito; Akira Shimada; Mika Saito; Hideki Muramatsu; Asahito Hama; Yoshiyuki Takahashi; Hirokazu Kimura; Seiji Kojima

doi:10.1097/MPH.0000000000000008

Long-term parvovirus B19 infections with genetic drift after cord blood transplantation complicated by persistent CD4⁺ lymphocytopenia

Michio Suzuki, Yoshinori Ito, Akira Shimada, Mika Saito, Hideki Muramatsu, Asahito Hama, Yoshiyuki Takahashi, Hirokazu Kimura, Seiji Kojima

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

A 5-month-old girl was diagnosed with Langerhans cell histiocytosis and received unrelated umbilical cord blood transplantation at the age of 14 months. After cord blood transplantation, CD4 lymphocytopenia from unknown causes was observed, and persistent infections with human parvovirus B19 (B19) occurred. We performed repeated longitudinal genetic analysis for B19, which revealed 6 nucleotide mutations in B19 nonstructural protein regions in the patient. The resulting changes of the nonstructural 1 structure may have altered antigenicity of the virus and could play a role in the pathogenesis of persistent infection under immunocompromised conditions.

Original language	English
Pages (from-to)	e65-e68
Journal	Journal of Pediatric Hematology/Oncology
Volume	36
Issue number	1
DOIs	https://doi.org/10.1097/MPH.0000000000000008
Publication status	Published - Jan 2014
Externally published	Yes

Keywords

Cord blood transplantation
Genetic drift
Lymphocytopenia
Parvovirus B19

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Hematology
Oncology

Access to Document

10.1097/MPH.0000000000000008

Cite this

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title = "Long-term parvovirus B19 infections with genetic drift after cord blood transplantation complicated by persistent CD4+ lymphocytopenia",

abstract = "A 5-month-old girl was diagnosed with Langerhans cell histiocytosis and received unrelated umbilical cord blood transplantation at the age of 14 months. After cord blood transplantation, CD4 lymphocytopenia from unknown causes was observed, and persistent infections with human parvovirus B19 (B19) occurred. We performed repeated longitudinal genetic analysis for B19, which revealed 6 nucleotide mutations in B19 nonstructural protein regions in the patient. The resulting changes of the nonstructural 1 structure may have altered antigenicity of the virus and could play a role in the pathogenesis of persistent infection under immunocompromised conditions.",

keywords = "Cord blood transplantation, Genetic drift, Lymphocytopenia, Parvovirus B19",

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T1 - Long-term parvovirus B19 infections with genetic drift after cord blood transplantation complicated by persistent CD4+ lymphocytopenia

AU - Suzuki, Michio

AU - Ito, Yoshinori

AU - Shimada, Akira

AU - Saito, Mika

AU - Muramatsu, Hideki

AU - Hama, Asahito

AU - Takahashi, Yoshiyuki

AU - Kimura, Hirokazu

AU - Kojima, Seiji

PY - 2014/1

Y1 - 2014/1

N2 - A 5-month-old girl was diagnosed with Langerhans cell histiocytosis and received unrelated umbilical cord blood transplantation at the age of 14 months. After cord blood transplantation, CD4 lymphocytopenia from unknown causes was observed, and persistent infections with human parvovirus B19 (B19) occurred. We performed repeated longitudinal genetic analysis for B19, which revealed 6 nucleotide mutations in B19 nonstructural protein regions in the patient. The resulting changes of the nonstructural 1 structure may have altered antigenicity of the virus and could play a role in the pathogenesis of persistent infection under immunocompromised conditions.

AB - A 5-month-old girl was diagnosed with Langerhans cell histiocytosis and received unrelated umbilical cord blood transplantation at the age of 14 months. After cord blood transplantation, CD4 lymphocytopenia from unknown causes was observed, and persistent infections with human parvovirus B19 (B19) occurred. We performed repeated longitudinal genetic analysis for B19, which revealed 6 nucleotide mutations in B19 nonstructural protein regions in the patient. The resulting changes of the nonstructural 1 structure may have altered antigenicity of the virus and could play a role in the pathogenesis of persistent infection under immunocompromised conditions.

KW - Cord blood transplantation

KW - Genetic drift

KW - Lymphocytopenia

KW - Parvovirus B19

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