TY - JOUR
T1 - Long-term Survival with a Rare Advanced Primary Gastrointestinal Malignant Melanoma Treated with Laparoscopic Surgery/Immune Checkpoint Inhibitor
AU - Endo, Motochika
AU - Yano, Shuuya
AU - Asano, Hiroaki
AU - Takeda, Sho
AU - Hamada, Yuki
AU - Kondo, Yoshitaka
AU - Kuroda, Shinji
AU - Shigeyasu, Kunitoshi
AU - Kikuchi, Satoru
AU - Tanaka, Takehiro
AU - Teraishi, Fuminori
AU - Nishizaki, Masahiko
AU - Kagawa, Shunsuke
AU - Fujiwara, Toshiyoshi
N1 - Publisher Copyright:
© 2021. All Rights Reserved.
PY - 2021
Y1 - 2021
N2 - Targeted therapies for malignant melanoma have improved patients' prognoses. A primary gastrointestinal malignant melanoma is very rare, with no standard treatment strategy. We treated a 78-year-old Japanese female with advanced primary gastrointestinal melanoma of the descending colon and gallbladder. We administered a multidisciplinary treatment: surgical resection of the descending colon and gallbladder tumors, resection of the metastatic lymph nodes behind the pancreas head, and immune checkpoint antibody-blockade therapy (nivolumab) for ~4 years. PET/CT demonstrated no recurrent lesion for >3 years. Multidisciplinary therapies (e.g., surgery, chemotherapy, radiotherapy, target therapy, and immune checkpoint antibody-blockade therapy) can successfully treat primary gastrointestinal malignant melanoma.
AB - Targeted therapies for malignant melanoma have improved patients' prognoses. A primary gastrointestinal malignant melanoma is very rare, with no standard treatment strategy. We treated a 78-year-old Japanese female with advanced primary gastrointestinal melanoma of the descending colon and gallbladder. We administered a multidisciplinary treatment: surgical resection of the descending colon and gallbladder tumors, resection of the metastatic lymph nodes behind the pancreas head, and immune checkpoint antibody-blockade therapy (nivolumab) for ~4 years. PET/CT demonstrated no recurrent lesion for >3 years. Multidisciplinary therapies (e.g., surgery, chemotherapy, radiotherapy, target therapy, and immune checkpoint antibody-blockade therapy) can successfully treat primary gastrointestinal malignant melanoma.
KW - immune checkpoint antibody-blockade inhibitor
KW - laparoscopic surgery
KW - primary gastrointestinal melanoma
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M3 - Article
C2 - 33953431
AN - SCOPUS:85105177770
SN - 0386-300X
VL - 75
SP - 231
EP - 238
JO - Acta medica Okayama
JF - Acta medica Okayama
IS - 2
ER -