Long-term treatment with hyperbaric air improves hy-perlipidemia of db/db mice

Kiyoshi Teshigawara, Toshio Hosaka, Miwa Yamaguchi, Eri Terada, Yuka Kisyuku, Keiko Fukunaga, Yohko Hirata, Bayasgalan Jambaldorj, Nagakatsu Harada, Tohru Sakai, Yutaka Nakaya

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)


Hyperbaric air (HBA) is used to improve healing of wounds including diabetic ulcer. The aim of this study was to clarify the effects of HBA exposure on lipid and glucose metabolism in db/db mice. HBA did not influence the weight of db/db mice. Serum levels of free fatty acid and triglyceride, but not glucose and insulin, were significantly decreased after 6 weeks of treatment with HBA. The mRNA expressions of CPT-1, PPARα and PGC-1α genes, which are related to lipid metabolism, were significantly up-regulated in the muscle and liver. Increases in TNFα and MCP1 mRNA, which impaired lipid metabolism, were also attenuated by HBA treatment. These results suggest that exposure of HBA could have beneficial effects on lipid metabolism in patients with type 2 diabetes mellitus.

Original languageEnglish
Pages (from-to)224-231
Number of pages8
JournalJournal of Medical Investigation
Issue number3-4
Publication statusPublished - Aug 2010
Externally publishedYes


  • HBA
  • Hyperlipidemia
  • MCP1
  • TNFα

ASJC Scopus subject areas

  • General Biochemistry,Genetics and Molecular Biology


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