Long-term treatment with the sodium glucose cotransporter 2 inhibitor, dapagliflozin, ameliorates glucose homeostasis and diabetic nephropathy in db/db mice

Agriculture & Biology

• sodium glucose cotransporter-2 inhibitors 100%
• diabetic nephropathy 79%
• homeostasis 39%
• albuminuria 38%
• oxidative stress 36%
• creatinine 35%
• fibrosis 28%
• hyperglycemia 28%
• glucose 27%
• mice 26%
• kidneys 24%
• blood pressure 22%
• gene expression 21%
• inflammation 21%
• dihydroethidium 19%
• chemokine CCL2 17%
• glycohemoglobin 17%
• osteopontin 16%
• transforming growth factors 15%
• noninsulin-dependent diabetes mellitus 14%
• NAD(P)H oxidase (H2O2-forming) 13%
• diabetes 12%
• blood glucose 11%
• cultured cells 10%
• cytokines 10%
• macrophages 10%
• animal models 10%
• epithelial cells 10%
• therapeutics 8%
• reverse transcriptase polymerase chain reaction 8%
• sodium 8%
• staining 8%
• cells 7%
• body weight 7%
• dosage 5%

Medicine & Life Sciences

• 2-(3-(4-ethoxybenzyl)-4-chlorophenyl)-6-hydroxymethyltetrahydro-2H-pyran-3,4,5-triol 72%
• Sodium-Glucose Transport Proteins 65%
• Diabetic Nephropathies 49%
• Homeostasis 33%
• Glucose 29%
• Oxidative Stress 19%
• Creatinine 15%
• Albuminuria 15%
• Hyperglycemia 12%
• Gene Expression 11%
• Kidney 10%
• NADPH Oxidase 4 10%
• dihydroethidium 10%
• Fibrosis 9%
• Blood Pressure 8%
• Osteopontin 7%
• Inflammation 7%
• Therapeutics 7%
• Chemokine CCL2 7%
• Transforming Growth Factors 6%
• Reverse Transcriptase Polymerase Chain Reaction 6%
• Cultured Cells 5%
• Blood Glucose 5%
• Hemoglobins 5%
• Type 2 Diabetes Mellitus 4%
• Anti-Inflammatory Agents 4%
• Epithelial Cells 4%
• Body Weight 4%
• Macrophages 4%
• Staining and Labeling 4%
• Cytokines 4%
• Serum 3%

Chemical Compounds

• Dapagliflozin 83%
• Glucose 34%
• Sodium Atom 29%
• Oxidative Stress 26%
• Creatinine 23%
• Blood Pressure 16%
• Clearance 14%
• Interstitial 13%
• Chemoattractant 9%
• Antiinflammatory 6%
• Hemoglobin 6%
• Antioxidant Agent 5%
• Weight 3%