TY - JOUR
T1 - Loss of HLA haplotype in lung cancer cell lines
T2 - Implications for immunosurveillance of altered HLA class I/II phenotypes in lung cancer
AU - Hiraki, Akio
AU - Kaneshige, Toshihiko
AU - Kiura, Katsuyuki
AU - Ueoka, Hiroshi
AU - Yamane, Hiromichi
AU - Tanaka, Motoyuki
AU - Harada, Mine
PY - 1999/4/1
Y1 - 1999/4/1
N2 - Loss of expression of HLA class I antigens has been demonstrated in a wide variety of tumors and is considered to be one of the mechanisms whereby tumors escape T-cell surveillance, Genomic DNA of MHC class I/II molecules in seven lung cancer cell lines was investigated and compared with that in peripheral blood mononuclear cells. In three cell lines, OU-LC-A1, OU-LC-A2, and OU-LC-AS1, a loss of HLA haplotype was observed. Aberrations of HLA class I/II in tumor cell lines should be considered when MHC-restricted phenomena in vitro models are assessed and clinical use of tumor vaccination in vivo is considered.
AB - Loss of expression of HLA class I antigens has been demonstrated in a wide variety of tumors and is considered to be one of the mechanisms whereby tumors escape T-cell surveillance, Genomic DNA of MHC class I/II molecules in seven lung cancer cell lines was investigated and compared with that in peripheral blood mononuclear cells. In three cell lines, OU-LC-A1, OU-LC-A2, and OU-LC-AS1, a loss of HLA haplotype was observed. Aberrations of HLA class I/II in tumor cell lines should be considered when MHC-restricted phenomena in vitro models are assessed and clinical use of tumor vaccination in vivo is considered.
UR - http://www.scopus.com/inward/record.url?scp=0032958294&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0032958294&partnerID=8YFLogxK
M3 - Article
C2 - 10213231
AN - SCOPUS:0032958294
SN - 1078-0432
VL - 5
SP - 933
EP - 936
JO - Clinical Cancer Research
JF - Clinical Cancer Research
IS - 4
ER -
