Background: Clinical usefulness of trazodone for delirium in patients receiving palliative care is unclear. Objectives: To examine the safety and effectiveness of trazodone for delirium. Design: A secondary analysis of a multicenter prospective observational study. Setting/Subjects: The setting involves nine psycho-oncology consultation services and 14 inpatient palliative care units in Japan. Measurements: The measurement involves the Delirium Rating Scale (DRS) Revised-98 for effectiveness and the CTCAE (Common Terminology Criteria for Adverse Events) version 4 for safety assessments. Results: Thirty-eight patients enrolled the study. Mean age was 75 years. After three-day observation, the DRS total score (11.6 5.3 to 8.7 6.5 [difference-2.9, 95% confidence interval-5.3 to-0.5, p = 0.02]); sleep-wake cycle disturbance (p = 0.047), lability of affect (p 0.001), and motor agitation subscales (p & 0.001) were significantly decreased. The most frequent adverse event was somnolence (n = 9). Conclusions: Low-dose trazodone treatment was generally safe and may be effective in reducing delirium severity.
|Number of pages||5|
|Journal||Journal of Palliative Medicine|
|Publication status||Published - Jun 2021|
- palliative care units
ASJC Scopus subject areas
- Anesthesiology and Pain Medicine