Lycopladines B-D and lyconadin B, new alkaloids from Lycopodium complanatum

Kan'ichiro Ishiuchi; Takaaki Kubota; Tomohiro Hoshino; Yutaro Obara; Norimichi Nakahata; Jun'ichi Kobayashi

doi:10.1016/j.bmc.2006.05.028

Lycopladines B-D and lyconadin B, new alkaloids from Lycopodium complanatum

Kan'ichiro Ishiuchi, Takaaki Kubota, Tomohiro Hoshino, Yutaro Obara, Norimichi Nakahata, Jun'ichi Kobayashi

Research output: Contribution to journal › Article › peer-review

64 Citations (Scopus)

Abstract

Four new alkaloids, lycopladines B-D (1-3) and lyconadin B (4), have been isolated from the club moss Lycopodium complanatum and the structures including the stereochemistry were elucidated on the basis of spectral data and modified Mosher's method. Lyconadin B (4) elevated NGF mRNA expression in 1321N1 human astrocytoma cells.

Original language	English
Pages (from-to)	5995-6000
Number of pages	6
Journal	Bioorganic and Medicinal Chemistry
Volume	14
Issue number	17
DOIs	https://doi.org/10.1016/j.bmc.2006.05.028
Publication status	Published - Sept 1 2006
Externally published	Yes

Keywords

Astrocytoma cells
Lyconadin B
Lycopladines B-D
Lycopodium alkaloids
NGF expression

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/j.bmc.2006.05.028

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title = "Lycopladines B-D and lyconadin B, new alkaloids from Lycopodium complanatum",

abstract = "Four new alkaloids, lycopladines B-D (1-3) and lyconadin B (4), have been isolated from the club moss Lycopodium complanatum and the structures including the stereochemistry were elucidated on the basis of spectral data and modified Mosher's method. Lyconadin B (4) elevated NGF mRNA expression in 1321N1 human astrocytoma cells.",

keywords = "Astrocytoma cells, Lyconadin B, Lycopladines B-D, Lycopodium alkaloids, NGF expression",

author = "Kan'ichiro Ishiuchi and Takaaki Kubota and Tomohiro Hoshino and Yutaro Obara and Norimichi Nakahata and Jun'ichi Kobayashi",

note = "Funding Information: The authors thank Prof. H. Morita, Hoshi University, for help with plant collection, Ms. S. Oka and Ms. M. Kiuchi, Center for Instrumental Analysis, Hokkaido University, for measurements of ESI-MS, and Mr. N. Yoshida, Health Sciences University of Hokkaido, for botanical identifications of the plant. This work was partly supported by a Grant-in-Aid for Scientific Research from the Ministry of Education, Science, Sports and Culture of Japan.",

year = "2006",

month = sep,

day = "1",

doi = "10.1016/j.bmc.2006.05.028",

language = "English",

volume = "14",

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journal = "Bioorganic and Medicinal Chemistry",

issn = "0968-0896",

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T1 - Lycopladines B-D and lyconadin B, new alkaloids from Lycopodium complanatum

AU - Ishiuchi, Kan'ichiro

AU - Kubota, Takaaki

AU - Hoshino, Tomohiro

AU - Obara, Yutaro

AU - Nakahata, Norimichi

AU - Kobayashi, Jun'ichi

N1 - Funding Information: The authors thank Prof. H. Morita, Hoshi University, for help with plant collection, Ms. S. Oka and Ms. M. Kiuchi, Center for Instrumental Analysis, Hokkaido University, for measurements of ESI-MS, and Mr. N. Yoshida, Health Sciences University of Hokkaido, for botanical identifications of the plant. This work was partly supported by a Grant-in-Aid for Scientific Research from the Ministry of Education, Science, Sports and Culture of Japan.

PY - 2006/9/1

Y1 - 2006/9/1

N2 - Four new alkaloids, lycopladines B-D (1-3) and lyconadin B (4), have been isolated from the club moss Lycopodium complanatum and the structures including the stereochemistry were elucidated on the basis of spectral data and modified Mosher's method. Lyconadin B (4) elevated NGF mRNA expression in 1321N1 human astrocytoma cells.

AB - Four new alkaloids, lycopladines B-D (1-3) and lyconadin B (4), have been isolated from the club moss Lycopodium complanatum and the structures including the stereochemistry were elucidated on the basis of spectral data and modified Mosher's method. Lyconadin B (4) elevated NGF mRNA expression in 1321N1 human astrocytoma cells.

KW - Astrocytoma cells

KW - Lyconadin B

KW - Lycopladines B-D

KW - Lycopodium alkaloids

KW - NGF expression

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SN - 0968-0896

VL - 14

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EP - 6000

JO - Bioorganic and Medicinal Chemistry

JF - Bioorganic and Medicinal Chemistry

IS - 17

ER -

Lycopladines B-D and lyconadin B, new alkaloids from Lycopodium complanatum

Abstract

Keywords

ASJC Scopus subject areas

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