Lymphadenoid Structure Induced by Gold Hypersensitivity

Keiji Iwatsuki, Hachiro Tagami, Takahiko Moriguchi, Mizuho Yamada

Research output: Contribution to journalArticlepeer-review

39 Citations (Scopus)


An allergic sensitivity to gold earrings produced a lymphadenoid reaction with germinal centers in the dermis of the pierced earlobes of a 21-year-old woman. However, a patch test for 1% gold sodium thiomalate gave a long-lasting, clinically and histologically eczematous response. Electron microscopic and cytochemical observations showed that non-T lymphocytes and plasma cells were dominant in the dermal infiltrate of the lesions, whereas lymphocytes with convoluted nuclei (which were probably T cells) and monocytes invaded the epidermis in the patch test site. These findings suggest that continuous exposure of the dermis to gold in a sensitized person may induce a lymphadenoid cellular reaction different from the histologic findings seen after contact with the epidermis.

Original languageEnglish
Pages (from-to)608-611
Number of pages4
JournalArchives of Dermatology
Issue number8
Publication statusPublished - Aug 1982

ASJC Scopus subject areas

  • Dermatology


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