Macrognathia secondary to dialysis-related renal osteodystrophy treated successfully by parathyroidectomy

Tsuyoshi Hata, I. Irei, K. Tanaka, H. Nagatsuka, M. Hosoda

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)


Renal osteodystrophy (ROD) is one of the most common complications affecting patients with chronic renal failure both before and after the initiation of maintenance dialysis, but macrognathia secondary to ROD is rare. Usually, enlarged jaws due to ROD do not return to their normal contours after the treatment of hyperparathyroidism. To the authors' knowledge, this article describes the second case of macrognathia secondary to dialysis-related ROD treated successfully by parathyroidectomy. Immunohistochemical study of the maxilla confirmed that parathyroidectomy could stop maladaptive parathyroid hormone stimulation, which leads not only to the formation of osteoblastic progenitors that become fibroblast-like cells but also to osteoclast formation.

Original languageEnglish
Pages (from-to)378-382
Number of pages5
JournalInternational Journal of Oral and Maxillofacial Surgery
Issue number4
Publication statusPublished - Apr 2006

ASJC Scopus subject areas

  • Surgery
  • Oral Surgery
  • Otorhinolaryngology


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