TY - JOUR
T1 - Macrognathia secondary to dialysis-related renal osteodystrophy treated successfully by parathyroidectomy
AU - Hata, Tsuyoshi
AU - Irei, I.
AU - Tanaka, K.
AU - Nagatsuka, H.
AU - Hosoda, M.
PY - 2006/4
Y1 - 2006/4
N2 - Renal osteodystrophy (ROD) is one of the most common complications affecting patients with chronic renal failure both before and after the initiation of maintenance dialysis, but macrognathia secondary to ROD is rare. Usually, enlarged jaws due to ROD do not return to their normal contours after the treatment of hyperparathyroidism. To the authors' knowledge, this article describes the second case of macrognathia secondary to dialysis-related ROD treated successfully by parathyroidectomy. Immunohistochemical study of the maxilla confirmed that parathyroidectomy could stop maladaptive parathyroid hormone stimulation, which leads not only to the formation of osteoblastic progenitors that become fibroblast-like cells but also to osteoclast formation.
AB - Renal osteodystrophy (ROD) is one of the most common complications affecting patients with chronic renal failure both before and after the initiation of maintenance dialysis, but macrognathia secondary to ROD is rare. Usually, enlarged jaws due to ROD do not return to their normal contours after the treatment of hyperparathyroidism. To the authors' knowledge, this article describes the second case of macrognathia secondary to dialysis-related ROD treated successfully by parathyroidectomy. Immunohistochemical study of the maxilla confirmed that parathyroidectomy could stop maladaptive parathyroid hormone stimulation, which leads not only to the formation of osteoblastic progenitors that become fibroblast-like cells but also to osteoclast formation.
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U2 - 10.1016/j.ijom.2005.08.006
DO - 10.1016/j.ijom.2005.08.006
M3 - Article
C2 - 16360304
AN - SCOPUS:33344454870
SN - 0901-5027
VL - 35
SP - 378
EP - 382
JO - International Journal of Oral and Maxillofacial Surgery
JF - International Journal of Oral and Maxillofacial Surgery
IS - 4
ER -