Ma'edamines A and B, cytotoxic bromotyrosine alkaloids with a unique 2(1H)pyrazinone ring from sponge Suberea sp.

Keiko Hirano; Takaaki Kubota; Masashi Tsuda; Kenji Watanabe; Jane Fromont; Jun'ichi Kobayashi

doi:10.1016/S0040-4020(00)00732-8

Ma'edamines A and B, cytotoxic bromotyrosine alkaloids with a unique 2(1H)pyrazinone ring from sponge Suberea sp.

Keiko Hirano, Takaaki Kubota, Masashi Tsuda, Kenji Watanabe, Jane Fromont, Jun'ichi Kobayashi

Research output: Contribution to journal › Article › peer-review

56 Citations (Scopus)

Abstract

Two new cytotoxic bromotyrosine alkaloids, ma'edamines A (1) and B (2), with a unique 2(1H)pyrazinone ring have been isolated from the Okinawan marine sponge Suberea sp. The structures were elucidated on the basis of spectroscopic data. (C) 2000 Elsevier Science Ltd.

Original language	English
Pages (from-to)	8107-8110
Number of pages	4
Journal	Tetrahedron
Volume	56
Issue number	41
DOIs	https://doi.org/10.1016/S0040-4020(00)00732-8
Publication status	Published - Oct 6 2000
Externally published	Yes

Keywords

Bromotyrosine alkaloid
Pyrazinone
Sponge

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/S0040-4020(00)00732-8

Cite this

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title = "Ma'edamines A and B, cytotoxic bromotyrosine alkaloids with a unique 2(1H)pyrazinone ring from sponge Suberea sp.",

abstract = "Two new cytotoxic bromotyrosine alkaloids, ma'edamines A (1) and B (2), with a unique 2(1H)pyrazinone ring have been isolated from the Okinawan marine sponge Suberea sp. The structures were elucidated on the basis of spectroscopic data. (C) 2000 Elsevier Science Ltd.",

keywords = "Bromotyrosine alkaloid, Pyrazinone, Sponge",

author = "Keiko Hirano and Takaaki Kubota and Masashi Tsuda and Kenji Watanabe and Jane Fromont and Jun'ichi Kobayashi",

note = "Funding Information: We thank Mr Z. Nagahama for his help with collection of the sponge and Banyu Pharmaceutical Co. Ltd for kinase assay. This work was partly supported by a grant-in-aid for Scientific Research from the Ministry of Education, Science, Sports and Culture of Japan.",

year = "2000",

month = oct,

day = "6",

doi = "10.1016/S0040-4020(00)00732-8",

language = "English",

volume = "56",

pages = "8107--8110",

journal = "Tetrahedron",

issn = "0040-4020",

publisher = "Elsevier Limited",

number = "41",

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TY - JOUR

T1 - Ma'edamines A and B, cytotoxic bromotyrosine alkaloids with a unique 2(1H)pyrazinone ring from sponge Suberea sp.

AU - Hirano, Keiko

AU - Kubota, Takaaki

AU - Tsuda, Masashi

AU - Watanabe, Kenji

AU - Fromont, Jane

AU - Kobayashi, Jun'ichi

N1 - Funding Information: We thank Mr Z. Nagahama for his help with collection of the sponge and Banyu Pharmaceutical Co. Ltd for kinase assay. This work was partly supported by a grant-in-aid for Scientific Research from the Ministry of Education, Science, Sports and Culture of Japan.

PY - 2000/10/6

Y1 - 2000/10/6

N2 - Two new cytotoxic bromotyrosine alkaloids, ma'edamines A (1) and B (2), with a unique 2(1H)pyrazinone ring have been isolated from the Okinawan marine sponge Suberea sp. The structures were elucidated on the basis of spectroscopic data. (C) 2000 Elsevier Science Ltd.

AB - Two new cytotoxic bromotyrosine alkaloids, ma'edamines A (1) and B (2), with a unique 2(1H)pyrazinone ring have been isolated from the Okinawan marine sponge Suberea sp. The structures were elucidated on the basis of spectroscopic data. (C) 2000 Elsevier Science Ltd.

KW - Bromotyrosine alkaloid

KW - Pyrazinone

KW - Sponge

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UR - http://www.scopus.com/inward/citedby.url?scp=0034612972&partnerID=8YFLogxK

U2 - 10.1016/S0040-4020(00)00732-8

DO - 10.1016/S0040-4020(00)00732-8

M3 - Article

AN - SCOPUS:0034612972

SN - 0040-4020

VL - 56

SP - 8107

EP - 8110

JO - Tetrahedron

JF - Tetrahedron

IS - 41

ER -

Ma'edamines A and B, cytotoxic bromotyrosine alkaloids with a unique 2(1H)pyrazinone ring from sponge Suberea sp.

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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