Magnetic resonance imaging and symptoms in patients with neurosarcoidosis and central diabetes insipidus

Seiji Adachi, Yusuke Fukuyasu, Yasuhiro Hashimoto, Shigehisa Sakurai, Akane Hirotani, Hisanori Danbara, Kaduyo Shimizu, Ryosuke Fujita, Hiroyuki Teraura, Kazuhiko Kotani, Masami Matsumura, Eiichi Kakehi

Research output: Contribution to journalReview articlepeer-review

4 Citations (Scopus)


Introduction: In the clinical setting, the diagnosis of neurosarcoidosis in patients with central diabetes insipidus (CDI) is typically based both on symptoms (i.e. polydipsia or polyuria) and brain magnetic resonance imaging (MRI) findings (e.g. pituitary abnormality). However, inconsistent changes in the patient’s symptoms and brain MRI findings may occur during the clinical course of the disease. This review was performed to summarise the relationship between symptoms and brain MRI findings in previously reported cases of neurosarcoidosis with CDI. Material and methods: Case studies of patients diagnosed with neurosarcoidosis with CDI were collected via a PubMed search of studies published through 30 June 2018. Results: Thirteen eligible studies were reviewed (20 patients; 12 men, 8 women; mean age 33 years). Polydipsia or polyuria was the first symptom in 13 patients. The mean duration from disease onset to diagnosis was 3.4 months. Brain MRIs showed abnormal findings in the hypothalamus and pituitary for 17 patients. Immunosuppressive drugs were used in 17 patients. For 14 patients, MRI findings improved, while symptoms did not. Conclusion: Patients with both neurosarcoidosis and CDI symptoms often do not improve, despite the fact that brain MRI findings often improve following treatment. More studies involving detailed pathological analyses and longer follow-up periods are necessary.

Original languageEnglish
Pages (from-to)430-437
Number of pages8
JournalEndokrynologia Polska
Issue number5
Publication statusPublished - 2019
Externally publishedYes


  • Central diabetes insipidus
  • Neurosarcoidosis
  • Pituitary
  • Pituitary stalk
  • Prednisolone

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology


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