TY - JOUR
T1 - Magnetic signal evaluation and imaging of magnetic nanoparticles in and ex vivo mouse brain specimen
AU - Washino, Masaomi
AU - Nomura, Kota
AU - Yamauchi, Kazuki
AU - Matsuda, Tetsuya
AU - Susumu, Yasuaki
AU - Seino, Satoshi
AU - Nakagawa, Takashi
AU - Sakane, Toshiyasu
AU - Kiwa, Toshihiko
AU - Tonooka, Shun
N1 - Funding Information:
This research was supported by the Advanced Measurement and Analysis Technology and Instrument Development Program of the Japan Agency for Medical Research and Development (project number 21 hm0102073).
Publisher Copyright:
© 2022 Washino et al.; licensee Infinite Science Publishing GmbH.
PY - 2022
Y1 - 2022
N2 - Magnetic Particle Imaging (MPI) is an imaging modality that directly detects the nonlinear response of magnetic nanoparticles (MNPs). Spatial encoding is realized by saturating the magnetic moment of MNPs most everywhere except in the special point called the field free reagion in which magnetic field vanishes. Recently, it has been shown that the sensitivity of MPI can be improved by using a field free line (FFL) in which the field free region formed as a line. We developed a MPI equipmemt with FFL using a neodymium magnet and an iron yoke, and magnetic particle imaging of a ex vivo mouse brain specimen was successfully performed. In addition, we studied the magnetization response of MNPs in the brain and found that the magnetic response of magnetic moment to external magnetic field in the brain is different from that in buffer solution.
AB - Magnetic Particle Imaging (MPI) is an imaging modality that directly detects the nonlinear response of magnetic nanoparticles (MNPs). Spatial encoding is realized by saturating the magnetic moment of MNPs most everywhere except in the special point called the field free reagion in which magnetic field vanishes. Recently, it has been shown that the sensitivity of MPI can be improved by using a field free line (FFL) in which the field free region formed as a line. We developed a MPI equipmemt with FFL using a neodymium magnet and an iron yoke, and magnetic particle imaging of a ex vivo mouse brain specimen was successfully performed. In addition, we studied the magnetization response of MNPs in the brain and found that the magnetic response of magnetic moment to external magnetic field in the brain is different from that in buffer solution.
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U2 - 10.18416/ijmpi.2022.2203036
DO - 10.18416/ijmpi.2022.2203036
M3 - Article
AN - SCOPUS:85128286786
SN - 2365-9033
VL - 8
JO - International Journal on Magnetic Particle Imaging
JF - International Journal on Magnetic Particle Imaging
IS - 1
M1 - 2203036
ER -