Magnetic signal evaluation and imaging of magnetic nanoparticles in and ex vivo mouse brain specimen

Masaomi Washino, Kota Nomura, Kazuki Yamauchi, Tetsuya Matsuda, Yasuaki Susumu, Satoshi Seino, Takashi Nakagawa, Toshiyasu Sakane, Toshihiko Kiwa, Shun Tonooka

Research output: Contribution to journalArticlepeer-review


Magnetic Particle Imaging (MPI) is an imaging modality that directly detects the nonlinear response of magnetic nanoparticles (MNPs). Spatial encoding is realized by saturating the magnetic moment of MNPs most everywhere except in the special point called the field free reagion in which magnetic field vanishes. Recently, it has been shown that the sensitivity of MPI can be improved by using a field free line (FFL) in which the field free region formed as a line. We developed a MPI equipmemt with FFL using a neodymium magnet and an iron yoke, and magnetic particle imaging of a ex vivo mouse brain specimen was successfully performed. In addition, we studied the magnetization response of MNPs in the brain and found that the magnetic response of magnetic moment to external magnetic field in the brain is different from that in buffer solution.

Original languageEnglish
Article number2203036
JournalInternational Journal on Magnetic Particle Imaging
Issue number1
Publication statusPublished - 2022

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Signal Processing
  • Radiology Nuclear Medicine and imaging
  • Computer Science Applications
  • Electrical and Electronic Engineering


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