Manifestation of central diabetes insipidus in a patient with thyroid storm

Akiko Nakamichi, Kazuki Ocho, Kosuke Oka, Miho Yasuda, Kou Hasegawa, Masaya Iwamuro, Mikako Obika, Kanmei Rai, Fumio Otsuka

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)


We herein report a case of central diabetes insipidus complicated with thyroid storm. A middle-aged woman who was receiving treatment for Graves’ disease suddenly complained of polydipsia, polyuria and general fatigue. Laboratory tests showed hyperthyroidism, hypernatremia, hypoosmolar urine and a decreased plasma vasopressin level. The occurrence of central diabetes insipidus with hyperthyroidism was revealed on the basis of pituitary magnetic resonance imaging, a water deprivation test and a desmopressin test. The clinical co-existence of diabetes insipidus and hyperthyroidism is very rare; however, the complication should be considered when hypernatremia and/or dehydration progress in patients with Graves’s disease as a common autoimmune-related etiology.

Original languageEnglish
Pages (from-to)1939-1942
Number of pages4
JournalInternal Medicine
Issue number13
Publication statusPublished - 2018


  • Central diabetes insipidus
  • Graves’ disease
  • Hyperthyroidism
  • Lymphocytic infundibulo-neurohypophysitis and thyroid crisis

ASJC Scopus subject areas

  • Internal Medicine


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