Manzamenones inhibit T-cell protein tyrosine phosphatase

Yusuke Wakuda; Takaaki Kubota; Hiroshi Shima; Tadashi Okada; Shinya Mitsuhashi; Naohito Aoki; Kunimi Kikuchi; Jun'ichi Kobayashi

doi:10.3390/md401009

Manzamenones inhibit T-cell protein tyrosine phosphatase

Yusuke Wakuda, Takaaki Kubota, Hiroshi Shima, Tadashi Okada, Shinya Mitsuhashi, Naohito Aoki, Kunimi Kikuchi, Jun'ichi Kobayashi

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

Manzamenones A-C (1-3) and E-F (5-6), unique oxylipin metabolites isolated from a marine sponge Plakortis sp., have been found to exhibit inhibitory activity against Tcell protein tyrosine phosphatase (TCPTP). The inhibitory activity of 2 and 5 against TCPTP was 4 times more potent than that against protein tyrosine phosphatase-1B (PTP1B).

Original language	English
Pages (from-to)	9-14
Number of pages	6
Journal	Marine Drugs
Volume	4
Issue number	1
DOIs	https://doi.org/10.3390/md401009
Publication status	Published - Mar 2006
Externally published	Yes

Keywords

Inhibitors
Manzamenones
Protein tyrosine phosphatases
TCPTP

ASJC Scopus subject areas

Drug Discovery

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3390/md401009

Cite this

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title = "Manzamenones inhibit T-cell protein tyrosine phosphatase",

abstract = "Manzamenones A-C (1-3) and E-F (5-6), unique oxylipin metabolites isolated from a marine sponge Plakortis sp., have been found to exhibit inhibitory activity against Tcell protein tyrosine phosphatase (TCPTP). The inhibitory activity of 2 and 5 against TCPTP was 4 times more potent than that against protein tyrosine phosphatase-1B (PTP1B).",

keywords = "Inhibitors, Manzamenones, Protein tyrosine phosphatases, TCPTP",

author = "Yusuke Wakuda and Takaaki Kubota and Hiroshi Shima and Tadashi Okada and Shinya Mitsuhashi and Naohito Aoki and Kunimi Kikuchi and Jun'ichi Kobayashi",

year = "2006",

month = mar,

doi = "10.3390/md401009",

language = "English",

volume = "4",

pages = "9--14",

journal = "Marine Drugs",

issn = "1660-3397",

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T1 - Manzamenones inhibit T-cell protein tyrosine phosphatase

AU - Wakuda, Yusuke

AU - Kubota, Takaaki

AU - Shima, Hiroshi

AU - Okada, Tadashi

AU - Mitsuhashi, Shinya

AU - Aoki, Naohito

AU - Kikuchi, Kunimi

AU - Kobayashi, Jun'ichi

PY - 2006/3

Y1 - 2006/3

N2 - Manzamenones A-C (1-3) and E-F (5-6), unique oxylipin metabolites isolated from a marine sponge Plakortis sp., have been found to exhibit inhibitory activity against Tcell protein tyrosine phosphatase (TCPTP). The inhibitory activity of 2 and 5 against TCPTP was 4 times more potent than that against protein tyrosine phosphatase-1B (PTP1B).

AB - Manzamenones A-C (1-3) and E-F (5-6), unique oxylipin metabolites isolated from a marine sponge Plakortis sp., have been found to exhibit inhibitory activity against Tcell protein tyrosine phosphatase (TCPTP). The inhibitory activity of 2 and 5 against TCPTP was 4 times more potent than that against protein tyrosine phosphatase-1B (PTP1B).

KW - Inhibitors

KW - Manzamenones

KW - Protein tyrosine phosphatases

KW - TCPTP

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UR - http://www.scopus.com/inward/citedby.url?scp=33646768997&partnerID=8YFLogxK

U2 - 10.3390/md401009

DO - 10.3390/md401009

M3 - Article

AN - SCOPUS:33646768997

SN - 1660-3397

VL - 4

SP - 9

EP - 14

JO - Marine Drugs

JF - Marine Drugs

IS - 1

ER -

Manzamenones inhibit T-cell protein tyrosine phosphatase

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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