Manzamenones inhibit T-cell protein tyrosine phosphatase

Yusuke Wakuda, Takaaki Kubota, Hiroshi Shima, Tadashi Okada, Shinya Mitsuhashi, Naohito Aoki, Kunimi Kikuchi, Jun'ichi Kobayashi

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)


Manzamenones A-C (1-3) and E-F (5-6), unique oxylipin metabolites isolated from a marine sponge Plakortis sp., have been found to exhibit inhibitory activity against Tcell protein tyrosine phosphatase (TCPTP). The inhibitory activity of 2 and 5 against TCPTP was 4 times more potent than that against protein tyrosine phosphatase-1B (PTP1B).

Original languageEnglish
Pages (from-to)9-14
Number of pages6
JournalMarine Drugs
Issue number1
Publication statusPublished - Mar 2006
Externally publishedYes


  • Inhibitors
  • Manzamenones
  • Protein tyrosine phosphatases

ASJC Scopus subject areas

  • Drug Discovery


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