Marked response to S-1 chemotherapy for para-aortic lymph node metastasis arising from gastric cancer

Fuminori Teraishi, Takeo Suzuki, Masako Nakamoto, Akira Chikuba, Masashi Nezu, Hiroshi Shimamura, Takao Takiue, Hiroshi Chikuba

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3 Citations (Scopus)


We report a recurrent case of gastric cancer with para-aortic lymph node metastasis that showed a marked response to systemic chemotherapy consisting of S-1 alone. A 70-year-old male was admitted to our hospital with appetite loss and left abdominal pain. He had a history of distal gastrectomy due to the advanced gastric cancer. Endoscopy revealed a submucosal tumor-like elevation with central ulcer, and the biopsy specimen was poorly-differentiated adenocarcinoma histologically. CT of the abdomen demonstrated a para-aortic lymph node swelling behind the remnant stomach, indicating an unresectable recurrent gastric cancer. We initially treated the patient with S-1 chemotherapy (60 mgx2/day) by oral administration. His tumor immediately responded to the chemotherapy, and restaging abdominal CT after 2 cycles of chemotherapy showed almost complete regression of lymph node metastasis. The patient has undergone S-1 chemotherapy and currently has remained in remission for more than 21 months with no severe adverse events. The S-1 regime was effective and safe, suggesting that S-1 could be the first-line chemotherapy for recurrent gastric cancer.

Original languageEnglish
Pages (from-to)1857-1859
Number of pages3
JournalGan to kagaku ryoho. Cancer & chemotherapy
Issue number11
Publication statusPublished - Nov 2007
Externally publishedYes

ASJC Scopus subject areas

  • General Medicine


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