Mast cell degranulating peptide forms voltage gated and cation-selective channels in lipid bilayers

Toru Ide, Takahisa Taguchi, Takuma Morita, Masayuki Sato, Kazuhiro Ikenaka, Saburo Aimoto, Tetsuro Kondo, Hironobu Hojo, Michiki Kasai, Katsuhiko Mikoshiba

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)

Abstract

Mast cell degranulating peptide, a toxin of bee venom, is a polypeptide composed of 22 amino acids. Exposure of the asolectin bilayer to the peptide results in the formation of channels that are more permeable to K+ than Cl-. These channels are activated when the voltage of the cis side, to which the peptide is added, is made positive.

Original languageEnglish
Pages (from-to)155-160
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume163
Issue number1
DOIs
Publication statusPublished - Aug 30 1989
Externally publishedYes

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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