TY - JOUR
T1 - Maternal gut microbiota in pregnancy influences offspring metabolic phenotype in mice
AU - Kimura, Ikuo
AU - Miyamoto, Junki
AU - Ohue-Kitano, Ryuji
AU - Watanabe, Keita
AU - Yamada, Takahiro
AU - Onuki, Masayoshi
AU - Aoki, Ryo
AU - Isobe, Yosuke
AU - Kashihara, Daiji
AU - Inoue, Daisuke
AU - Inaba, Akihiko
AU - Takamura, Yuta
AU - Taira, Satsuki
AU - Kumaki, Shunsuke
AU - Watanabe, Masaki
AU - Ito, Masato
AU - Nakagawa, Fumiyuki
AU - Irie, Junichiro
AU - Kakuta, Hiroki
AU - Shinohara, Masakazu
AU - Iwatsuki, Ken
AU - Tsujimoto, Gozoh
AU - Ohno, Hiroaki
AU - Arita, Makoto
AU - Itoh, Hiroshi
AU - Hase, Koji
N1 - Funding Information:
We thank K. Igarashi for metabolome analysis; A. Nagata for SCFA analysis; M. Arita and S. Kasuga for in vitro assay; and T. Sasaki, M. Akehi, and H. Hirano for PET imaging. This work was supported by research grants from the JSPS KAKENHI (JP17H05344 to I.K., JP15H05897 and JP15H05898 to M.A., and JP18H04680 and JP17KT0055 to K.H.), AMED (JP18gm1010007 to I.K. and JP18gm1010004h0103 to K.H.), the Lotte Foundation (to I.K.), the Institute for Fermentation Osaka (to I.K.), the Takeda Science Foundation (to H.K.), the Asahi Grass Foundation (to K.H.), and the Yakult Science Foundation (to K.H.).
Publisher Copyright:
Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works
PY - 2020/2/28
Y1 - 2020/2/28
N2 - Antibiotics and dietary habits can affect the gut microbial community, thus influencing disease susceptibility. Although the effect of microbiota on the postnatal environment has been well documented, much less is known regarding the impact of gut microbiota at the embryonic stage. Here we show that maternal microbiota shapes the metabolic system of offspring in mice. During pregnancy, short-chain fatty acids produced by the maternal microbiota dictate the differentiation of neural, intestinal, and pancreatic cells through embryonic GPR41 and GPR43. This developmental process helps maintain postnatal energy homeostasis, as evidenced by the fact that offspring from germ-free mothers are highly susceptible to metabolic syndrome, even when reared under conventional conditions. Thus, our findings elaborate on a link between the maternal gut environment and the developmental origin of metabolic syndrome.
AB - Antibiotics and dietary habits can affect the gut microbial community, thus influencing disease susceptibility. Although the effect of microbiota on the postnatal environment has been well documented, much less is known regarding the impact of gut microbiota at the embryonic stage. Here we show that maternal microbiota shapes the metabolic system of offspring in mice. During pregnancy, short-chain fatty acids produced by the maternal microbiota dictate the differentiation of neural, intestinal, and pancreatic cells through embryonic GPR41 and GPR43. This developmental process helps maintain postnatal energy homeostasis, as evidenced by the fact that offspring from germ-free mothers are highly susceptible to metabolic syndrome, even when reared under conventional conditions. Thus, our findings elaborate on a link between the maternal gut environment and the developmental origin of metabolic syndrome.
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U2 - 10.1126/science.aaw8429
DO - 10.1126/science.aaw8429
M3 - Article
C2 - 32108090
AN - SCOPUS:85080911530
SN - 0036-8075
VL - 367
JO - Science
JF - Science
IS - 6481
M1 - eaaw8429
ER -