Mechanism of bradykinin-induced histamine release from rat peritoneal mast cells

Qiu E. Zhao, Takuma Mihara, Yukio Sugimoto, Chiaki Kamei

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)


Bradykinin at concentrations higher than 2 μM caused a significant histamine release from rat peritoneal mast cells when extracellular Ca2+ was removed from the medium. Under the same experimental conditions, bradykinin increased Ca2+ release from the intracellular Ca store of the rat peritoneal mast cells, and a clear relationship was observed between the magnitude of histamine release and an increase in fluorescence intensity. Addition of Ca2+ to the medium resulted in an inhibition of the response to bradykinin in a concentration-dependent manner. Almost the same results were obtained when Mg2+, Ba2+ and La3+ were added to the medium. Neither B1 nor B2 antagonists caused significant antagonistic effects on histamine release induced by bradykinin. However, B2 antagonists caused a histamine release of the same potency as bradykinin when applied alone. These results indicate that bradykinin-induced histamine release is not attributable to a bradykinin receptor.

Original languageEnglish
Pages (from-to)237-240
Number of pages4
JournalBiological and Pharmaceutical Bulletin
Issue number2
Publication statusPublished - Feb 1996


  • bradykinin
  • histamine release
  • intracellular Ca release
  • mast cell

ASJC Scopus subject areas

  • Pharmacology
  • Pharmaceutical Science


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