Mechanism of hematuria - I. Electron microscopic demonstration of the passage of a red blood cell through a glomerular capillary wall in rat masugi nephritis

Hirofumi Makino; Shigeaki Nishimura; Kenji Soda; Michio Takaoka; Tetsuji Kaneshige; Zensuke Ota

doi:10.1007/BF02889902

Mechanism of hematuria - I. Electron microscopic demonstration of the passage of a red blood cell through a glomerular capillary wall in rat masugi nephritis

Hirofumi Makino, Shigeaki Nishimura, Kenji Soda, Michio Takaoka, Tetsuji Kaneshige, Zensuke Ota

Research output: Contribution to journal › Article › peer-review

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Abstract

Masugi nehpritis was induced in Sprague-Dawley rats by an intravenous injection of rabbit anti-rat kidney serum. In the autologous phase of the disease, three of 18 rats manifested continuous hematuria. Ultrastructural examination of renal glomeruli by transmission and scanning microscopy revealed gaps in the basement membranes, and the transcapillary passage of red blood cells through the discontinuous regions in the hematuric rats. Control animals revealed no gaps in the glomerular basement membranes regardless of the method used in their preparation for electron microscopy. These data support the hypothesis that hematuria is a result of the passage of red blood cells through gaps in the glomerular basement membrane in Masugi nephritis.

Original language	English
Pages (from-to)	199-208
Number of pages	10
Journal	Virchows Archiv B Cell Pathology Including Molecular Pathology
Volume	50
Issue number	1
DOIs	https://doi.org/10.1007/BF02889902
Publication status	Published - Dec 1 1986

Keywords

Acellular kidney
Glomerular basement membrane
Hematuria
Nephrotoxic nephritis
Scanning electron microscopy

ASJC Scopus subject areas

Pathology and Forensic Medicine

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10.1007/BF02889902

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Mechanism of hematuria - I. Electron microscopic demonstration of the passage of a red blood cell through a glomerular capillary wall in rat masugi nephritis. / Makino, Hirofumi; Nishimura, Shigeaki; Soda, Kenji et al.
In: Virchows Archiv B Cell Pathology Including Molecular Pathology, Vol. 50, No. 1, 01.12.1986, p. 199-208.

Research output: Contribution to journal › Article › peer-review

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abstract = "Masugi nehpritis was induced in Sprague-Dawley rats by an intravenous injection of rabbit anti-rat kidney serum. In the autologous phase of the disease, three of 18 rats manifested continuous hematuria. Ultrastructural examination of renal glomeruli by transmission and scanning microscopy revealed gaps in the basement membranes, and the transcapillary passage of red blood cells through the discontinuous regions in the hematuric rats. Control animals revealed no gaps in the glomerular basement membranes regardless of the method used in their preparation for electron microscopy. These data support the hypothesis that hematuria is a result of the passage of red blood cells through gaps in the glomerular basement membrane in Masugi nephritis.",

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AU - Takaoka, Michio

AU - Kaneshige, Tetsuji

AU - Ota, Zensuke

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Mechanism of hematuria - I. Electron microscopic demonstration of the passage of a red blood cell through a glomerular capillary wall in rat masugi nephritis

Abstract

Keywords

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