Mechanisms of progranulin action and regulation in genitourinary cancers

Ryuta Tanimoto, Kuojung G. Lu, Shi Qiong Xu, Simone Buraschi, Antonino Belfiore, Renato V. Iozzo, Andrea Morrione

Research output: Contribution to journalReview articlepeer-review

21 Citations (Scopus)


The growth factor progranulin has emerged in recent years as a critical regulator of transformation in several cancer models, including breast cancer, glioblastomas, leukemias, and hepatocellular carcinomas. Several laboratories, including ours, have also demonstrated an important role of progranulin in several genitourinary cancers, including ovarian, endometrial, cervical, prostate, and bladder tumors, where progranulin acts as an autocrine growth factor thereby modulating motility and invasion of transformed cells. In this review, we will focus on the mechanisms of action and regulation of progranulin signaling in genitourinary cancers with a special emphasis on prostate and bladder tumors.

Original languageEnglish
Article number100
JournalFrontiers in Endocrinology
Issue numberJUL
Publication statusPublished - Jul 27 2016
Externally publishedYes


  • Anchorage-independent growth
  • Bladder and prostate cancer
  • Motility
  • Progranulin
  • Tumor formation in vivo

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism


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