Mechanisms of tumor development and anti-angiogenic therapy in glioblastoma multiforme

Manabu Onishi, Kazuhiko Kurozumi, Tomotsugu Ichikawa, Isao Date

Research output: Contribution to journalArticlepeer-review

22 Citations (Scopus)


Despite advances in surgical and medical therapy, glioblastoma multiforme (GBM) remains a fatal disease. There has been no significant increase in survival for patients with this disease over the last 20 years. Tumor vasculature formation and glioma cell invasion along the white matter tracts both play a pivotal role in glioma development. Angiogenesis and invasion are the major factors believed to be responsible for treatment resistance in tumors, and a better understanding of the glioma invasion and angiogenesis mechanisms will lead to the development of potential new treatments. In this review, we focus on the molecular characteristics of angiogenesis and invasion in human malignant glioma. We discuss bevacizumab and cilengitide, which are used to inhibit angiogenesis in GBM.

Original languageEnglish
Pages (from-to)755-763
Number of pages9
Journalneurologia medico-chirurgica
Issue number11
Publication statusPublished - 2013
Externally publishedYes


  • Angiogenesis
  • Bevacizumab
  • Cilengitide
  • Invasion

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology


Dive into the research topics of 'Mechanisms of tumor development and anti-angiogenic therapy in glioblastoma multiforme'. Together they form a unique fingerprint.

Cite this