Medium- or long-term follow-up for choroidal neovascularization with transpupillary thermotherapy

Ippei Takasu, Fumio Shiraga, Hidetaka Yamaji, Hiroshi Ohtsuki

Research output: Contribution to journalArticlepeer-review


Purpose: To evaluate the efficacy of transpupillary thermotherapy (TTT) for choroidal neovascularization (CNV). Methods: TTT was performed in 32 cases of subfoveal CNV. The patients were followed up with measurements of visual acuity (VA), fundus examinations, angiography, and optical coherence tomography for more than 6 months after the procedure. Results: Mean VA was 0.12 before TTT, 0.09 at 6 months after TTT, and 0.05 at 12 months after TTT. At the latest visit, VA improved by 2 levels or more in 13% of the patients, was maintained in 59%, and decreased by 2 levels or more in 28%. The results of ophthalmoscopy or angiography showed that CNV activity was decreased in 50% of patients and increased in 31%. The irradiated areas progressed to chorioretinal atrophy in 6 eyes (19%). In 11 of 26 eyes that underwent ophthalmic examination within 7 days after TTT, macular edema, fluorescein dye leakage from retinal vessels, and/or occlusion of retinal capillaries were seen. They all improved within 1 month after TTT. Conclusions: TTT is one potential treatment for CNV. For optimal use of this therapy, however, further evaluation is needed.

Original languageEnglish
Pages (from-to)519-524
Number of pages6
JournalFolia Ophthalmologica Japonica
Issue number7
Publication statusPublished - 2003
Externally publishedYes


  • Age-Related Macular Degeneration
  • Choroidal Neovascularization
  • Polypoidal Choroidal Vasculopathy
  • Transpupillary Thermotherapy

ASJC Scopus subject areas

  • Ophthalmology


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