Mesenchymal stem cell therapy for ischemic stroke

Atsuhiko Toyoshima, Takao Yasuhara, Isao Date

Research output: Contribution to journalReview articlepeer-review

29 Citations (Scopus)


To date, many animal studies have indicated the neuroprotective effects of mesenchymal stem cell (MSC) transplantation in ischemic stroke. Several clinical studies have also revealed the safety, feasibility, and neuroprotective effects in ischemic stroke patients. In this review, we present the main approaches of MSC transplantation in ischemic stroke, the mechanisms of MSC therapy, and the current clinical studies on MSC transplantation in ischemic stroke patients. We also explore the safety of MSC transplantation and conclude that MSC therapy will play an important role in the future treatment of ischemic stroke. The optimal timing, approach, and cell dose in the transplantation are important issues for successful clinical application.

Original languageEnglish
Pages (from-to)263-268
Number of pages6
JournalActa medica Okayama
Issue number4
Publication statusPublished - 2017


  • Cell transplantation
  • Clinical trial
  • Ischemic stroke
  • Mesenchymal stem cell

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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