Metabolism of chloral hydrate in the anoxic perfused liver

Toshihiro Kawamoto; Tatsuya Hobara; Tatsuya Aoki; Haruo Kobayashi; Susumu Iwamoto; Tsunemi Sakai; Takehito Takano; Yoshifumi Miyazaki; Akihisa Imamura; Keiki Ogino

doi:10.1016/0378-4274(88)90045-8

Metabolism of chloral hydrate in the anoxic perfused liver

Toshihiro Kawamoto, Tatsuya Hobara, Tatsuya Aoki, Haruo Kobayashi, Susumu Iwamoto, Tsunemi Sakai, Takehito Takano, Yoshifumi Miyazaki, Akihisa Imamura, Keiki Ogino

Graduate School of Medicine Dentistry and Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

The metabolism of chloral hydrate (CH) under anoxic conditions was investigated in the non-recirculating, hemoglobin-free liver perfusion system. CH uptake in the anoxic liver decreased to about 80% of that in the oxygen-supplied liver. The reduction of CH to trichloroethanol (TCE) increased and the oxidation of CH to trichloroacetic acid (TCA) decreased. The TCE/TCA ratio increased; however, the total trichloro compounds, that is TCE and TCA, were not significantly altered by anoxia. Though approximate 14% of the CH infused into the oxygen-supplied liver was changed to substances other than TCE or TCA, the unknown part was a very small portion in the anoxic liver. The decrease in CH uptake, by the anoxic liver, is thought to be equivalent to the decrease of the unknown metabolites. The TCE/TCA ratio under anoxia was also altered by pyruvate or lactate infusion.

Original language	English
Pages (from-to)	225-231
Number of pages	7
Journal	Toxicology Letters
Volume	40
Issue number	3
DOIs	https://doi.org/10.1016/0378-4274(88)90045-8
Publication status	Published - Mar 1988

Keywords

Anoxia
Chloral hydrate: Trichloroethanol
Drug metabolism
Liver
Perfusion
Trichloroacetic acid

ASJC Scopus subject areas

Toxicology

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10.1016/0378-4274(88)90045-8

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title = "Metabolism of chloral hydrate in the anoxic perfused liver",

abstract = "The metabolism of chloral hydrate (CH) under anoxic conditions was investigated in the non-recirculating, hemoglobin-free liver perfusion system. CH uptake in the anoxic liver decreased to about 80% of that in the oxygen-supplied liver. The reduction of CH to trichloroethanol (TCE) increased and the oxidation of CH to trichloroacetic acid (TCA) decreased. The TCE/TCA ratio increased; however, the total trichloro compounds, that is TCE and TCA, were not significantly altered by anoxia. Though approximate 14% of the CH infused into the oxygen-supplied liver was changed to substances other than TCE or TCA, the unknown part was a very small portion in the anoxic liver. The decrease in CH uptake, by the anoxic liver, is thought to be equivalent to the decrease of the unknown metabolites. The TCE/TCA ratio under anoxia was also altered by pyruvate or lactate infusion.",

keywords = "Anoxia, Chloral hydrate: Trichloroethanol, Drug metabolism, Liver, Perfusion, Trichloroacetic acid",

author = "Toshihiro Kawamoto and Tatsuya Hobara and Tatsuya Aoki and Haruo Kobayashi and Susumu Iwamoto and Tsunemi Sakai and Takehito Takano and Yoshifumi Miyazaki and Akihisa Imamura and Keiki Ogino",

year = "1988",

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doi = "10.1016/0378-4274(88)90045-8",

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T1 - Metabolism of chloral hydrate in the anoxic perfused liver

AU - Kawamoto, Toshihiro

AU - Hobara, Tatsuya

AU - Aoki, Tatsuya

AU - Kobayashi, Haruo

AU - Iwamoto, Susumu

AU - Sakai, Tsunemi

AU - Takano, Takehito

AU - Miyazaki, Yoshifumi

AU - Imamura, Akihisa

AU - Ogino, Keiki

PY - 1988/3

Y1 - 1988/3

N2 - The metabolism of chloral hydrate (CH) under anoxic conditions was investigated in the non-recirculating, hemoglobin-free liver perfusion system. CH uptake in the anoxic liver decreased to about 80% of that in the oxygen-supplied liver. The reduction of CH to trichloroethanol (TCE) increased and the oxidation of CH to trichloroacetic acid (TCA) decreased. The TCE/TCA ratio increased; however, the total trichloro compounds, that is TCE and TCA, were not significantly altered by anoxia. Though approximate 14% of the CH infused into the oxygen-supplied liver was changed to substances other than TCE or TCA, the unknown part was a very small portion in the anoxic liver. The decrease in CH uptake, by the anoxic liver, is thought to be equivalent to the decrease of the unknown metabolites. The TCE/TCA ratio under anoxia was also altered by pyruvate or lactate infusion.

AB - The metabolism of chloral hydrate (CH) under anoxic conditions was investigated in the non-recirculating, hemoglobin-free liver perfusion system. CH uptake in the anoxic liver decreased to about 80% of that in the oxygen-supplied liver. The reduction of CH to trichloroethanol (TCE) increased and the oxidation of CH to trichloroacetic acid (TCA) decreased. The TCE/TCA ratio increased; however, the total trichloro compounds, that is TCE and TCA, were not significantly altered by anoxia. Though approximate 14% of the CH infused into the oxygen-supplied liver was changed to substances other than TCE or TCA, the unknown part was a very small portion in the anoxic liver. The decrease in CH uptake, by the anoxic liver, is thought to be equivalent to the decrease of the unknown metabolites. The TCE/TCA ratio under anoxia was also altered by pyruvate or lactate infusion.

KW - Anoxia

KW - Chloral hydrate: Trichloroethanol

KW - Drug metabolism

KW - Liver

KW - Perfusion

KW - Trichloroacetic acid

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Metabolism of chloral hydrate in the anoxic perfused liver

Abstract

Keywords

ASJC Scopus subject areas

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