Metabolism of chloral hydrate in the anoxic perfused liver

Toshihiro Kawamoto, Tatsuya Hobara, Tatsuya Aoki, Haruo Kobayashi, Susumu Iwamoto, Tsunemi Sakai, Takehito Takano, Yoshifumi Miyazaki, Akihisa Imamura, Keiki Ogino

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)


The metabolism of chloral hydrate (CH) under anoxic conditions was investigated in the non-recirculating, hemoglobin-free liver perfusion system. CH uptake in the anoxic liver decreased to about 80% of that in the oxygen-supplied liver. The reduction of CH to trichloroethanol (TCE) increased and the oxidation of CH to trichloroacetic acid (TCA) decreased. The TCE/TCA ratio increased; however, the total trichloro compounds, that is TCE and TCA, were not significantly altered by anoxia. Though approximate 14% of the CH infused into the oxygen-supplied liver was changed to substances other than TCE or TCA, the unknown part was a very small portion in the anoxic liver. The decrease in CH uptake, by the anoxic liver, is thought to be equivalent to the decrease of the unknown metabolites. The TCE/TCA ratio under anoxia was also altered by pyruvate or lactate infusion.

Original languageEnglish
Pages (from-to)225-231
Number of pages7
JournalToxicology Letters
Issue number3
Publication statusPublished - Mar 1988


  • Anoxia
  • Chloral hydrate: Trichloroethanol
  • Drug metabolism
  • Liver
  • Perfusion
  • Trichloroacetic acid

ASJC Scopus subject areas

  • Toxicology


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